Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Developing a computer aided design tool for inclusive design [PDF]
, 2005 The purpose of this study was to investigate age-related changes in the performance of a range of movement tasks for integration into a computer aided design (CAD) tool for use in inclusive ...
Conway, Bernard +4 more
core
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Predatory conferences: A threat to scientific integrity
Baghdad Journal of Biochemistry and Applied Biological Sciences, 2023 Hussein A. Abid +2 more
doaj +1 more source
Ion Channels Prominent at Key U.S. and U.K. Conferences [PDF]
, 2019 Sophie Rose, Marc Rogers
openalex +1 more source
Addressing the underrepresentation of women in mathematics conferences [PDF]
, 2015 Despite significant improvements over the last few generations, the discipline of mathematics still counts a disproportionately small number of women among its practitioners.
Martin, Greg
core
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
FEBS Open Bio, EarlyView.Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source
The 8th International Evidence Based Library and Information Practice Conference (EBLIP8):
Evidence Based Library and Information Practice, 2015 The conference theme “Evidence and practice: Working together” reflected our focus on narrowing the gap between practice and evidence, and in promoting evidence based practice in all parts of the information profession.
Helen Partridge
doaj