Results 51 to 60 of about 295,121 (236)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
This is my First One: Finding and Building Community at RDAP Summit 2019
Journal of eScience Librarianship, 2019 This commentary depicts the experiences and thoughts of both a first-time attendee to the Research Data Access and Preservation (RDAP) Summit held May 2019 and of a library/data-related conference.
Ateanna Uriri
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Business tourism under apartheid: The historical development of South Africa’s conference industry
Urbani Izziv, 2019 Conference tourism as part of MICE tourism has attracted a growing international literature. It is argued existing scholarship is overwhelmingly ‘present-minded’ and that historical issues relating to the conference industry often are overlooked.
Christian M. ROGERSON
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Bubble universe from flat spaces
European Physical Journal C: Particles and FieldsWe show by matching two flat spaces one in Minkowski coordinates ( empty space) and the other in Minkowski coordinates after a special conformal transformation (also empty space) through a bubble with positive and constant surface tension, that the ...
Eduardo Guendelman, Jacov Portnoy
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
A cinematographic analysis of English-dubbed Korean films
Humanities & Social Sciences CommunicationsThis study investigates dubbing strategies used in Korean-to-English film translations to identify differences between on-screen and off-screen dubbing.
Miseon Yoon
doaj +1 more source