Results 71 to 80 of about 394,858 (255)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The Level of students' mathematical creative thinking skills as measured by their self-confidence
International Journal of Didactic Mathematics in Distance EducationHigh self-confidence and creative mathematical thinking skills will change students from having difficulty with mathematics to active learners who can solve mathematical problems.
Neng Syntadewi Efwan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
BMC Bioinformatics, 2012 Background Affinity-Purification Mass-Spectrometry (AP-MS) provides a powerful means of identifying protein complexes and interactions. Several important challenges exist in interpreting the results of AP-MS experiments.
Dazard Jean-Eudes +2 more
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Examining Confidence Accuracy, Observation Skills, and the Dunning Kruger Effect
Journal of Innovation in Polytechnic EducationUsing a quantitative approach, this study examines the confidence accuracy relationship of eyewitness memory and observation skills and explores the relationship between self-perception and accuracy (The Dunning Kruger Effect).
Megan Sheridan +2 more
doaj +1 more source
Penguatan Sikap Percaya Diri melalui Dreams Book bagi Siswa Kelas I SDN Tegalombo I Kalijambe Sragen
At-Tarbawi, 2016 This article aims to explore the reinforcement of confidence through dreams book. In the early condition, the students have low self-confidence. To increase theself-confidence of the students, the teacher begins to explore the dreams of the students and ...
Yan Vita
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Evolutional expediency of innovations of different novelty [PDF]
Marketing i Menedžment Innovacij, 2016 Efficiency of innovative idea selection may be increased if the methodology of indicative estimation of expediency of innovative project realization on principles of its evolutional correctness (EC) and efficiency (EE) is applied.
L.K. Hlinenko
doaj
IEEE Access, 2018 It is essential to enhance the speed and accuracy of the localization process to gain the robustness and instantaneous properties and to adapt from the practical environment of a confidence band.
Frank Po-Chen Lin +1 more
doaj +1 more source