Results 51 to 60 of about 2,097,293 (339)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

A method for uncertainty and sensitivity analysis in fuel performance codes

open access: yesBrazilian Journal of Radiation Sciences, 2021
The present study proposes a method for the execution of uncertainty and sensitivity analysis on TRANSURANUS code, adapted for the use of stainless steel AISI-348 as the cladding material for a PWR reactor fuel rod, thus allowing to determine which input
Ana Carolina Bortoletto Dantas   +1 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Shapley Value Confidence Intervals for Attributing Variance Explained

open access: yesFrontiers in Applied Mathematics and Statistics, 2020
The coefficient of determination, the R2, is often used to measure the variance explained by an affine combination of multiple explanatory covariates. An attribution of this explanatory contribution to each of the individual covariates is often sought in
Daniel Fryer, Inga Strümke, Hien Nguyen
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Democratic Confidence Intervals for comparing two Proportions [PDF]

open access: yesSongklanakarin Journal of Science and Technology (SJST), 2013
We offer methods to create an accurate graph for comparing confidence intervals for two proportions. The firstmethod involves using weighted sum contrasts when fitting logistic regression with a binary explanatory variable.
Phattrawan Tongkumchum   +3 more
doaj  

Alternatives to P value: confidence interval and effect size [PDF]

open access: yesKorean Journal of Anesthesiology, 2016
The previous articles of the Statistical Round in the Korean Journal of Anesthesiology posed a strong enquiry on the issue of null hypothesis significance testing (NHST).
Dong Kyu Lee
doaj   +1 more source

Estimating confidence intervals for transport Mode share. [PDF]

open access: yes, 2005
One of the common statistics used to monitor transport activity is the total travel by a particular method or mode and, for each mode, this share is routinely expressed as a percentage of total personal travel.
Clark, S.D., McKimm, J.
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

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