Results 71 to 80 of about 25,927 (280)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Configurational Entropy and its Crisis in Metastable States: Ideal Glass Transition in a Dimer Model as a Paragidm of a Molecular Glass [PDF]

, 2004
We discuss the need for discretization to evaluate the configurational entropy in a general model. We also discuss the prescription using restricted partition function formalism to study the stationary limit of metastable states.
A. L. Fetter, C. A. Angell, C. A. Angell, C. J. Thompson, D. Ruelle, E. A. Di Marzio, E. A. DiMarzio, E. W. Fischer, F. Semerianov, L. D. Landau, M. Toda, O. Penrose, P. D. Gujrati, P. D. Gujrati, P. D. Gujrati, P. D. Gujrati, P. G. Debenedetti, P. W. Anderson, W. Gotze, W. Kauzmann   +19 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Evaluation of configurational entropy of a model liquid from computer simulations

, 2000
Computer simulations have been employed in recent years to evaluate the configurational entropy changes in model glass-forming liquids. We consider two methods, both of which involve the calculation of the `intra-basin' entropy as a means for obtaining ...
Adam G, Cardenas M, Gibbs J H, Sastry S, Scala A, Scala A, Schröder T B, Sciortino F, Speedy R, Speedy R J, Speedy R J, Srikanth Sastry, Stillinger F H, Stillinger F H   +13 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Metastable states in glassy systems

, 2000
Truly stable metastable states are an artifact of the mean-field approximation or the zero temperature limit. If such appealing concepts in glass theory as configurational entropy are to have a meaning beyond these approximations, one needs to cast them ...
A. Barrat, A. Bray, A. Cavagna, A. Crisanti, A. J. Bray, A. J. Bray, A. Mehta, A. V. Lopatin, B. Coluzzi, B. Gaveau, B. Gaveau, B. Gaveau, B. Gaveau, C. De Dominicis, D. J. Thouless, D. Thirumalai, E. Witten, F. Sciortino, G. Biroli, G. Biroli, G. Biroli, G. Parisi, G. Parisi, Giulio Biroli, H. Rieger, J. Kurchan, J. Kurchan, J. Zinn-Justin, Jorge Kurchan, L. B. Ioffe, L. F. Cugliandolo, L. F. Cugliandolo, L. F. Cugliandolo, L. L. Bonilla, M. Mézard, M. Mézard, M. Mézard, M. Sellitto, P. H. Stillinger, P. H. Stillinger, R. Melin, R. Melin, R. Monasson, R. Monasson, S. F. Edwards, S. Franz, S. Franz, S. Franz, T. R. Kirkpatrick, T. R. Kirkpatrick, T. R. Kirkpatrick, T. R. Kirkpatrick, T. R. Kirkpatrick, T. R. Kirkpatrick, T. R. Kirkpatrick, T. W. Ruijgrok, Th. M. Nieuwenhuizen, W. Kob, W. Kob   +58 more
core   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

Hopfield Neural Networks for Online Constrained Parameter Estimation With Time‐Varying Dynamics and Disturbances

International Journal of Adaptive Control and Signal Processing, EarlyView.
This paper proposes two projector‐based Hopfield neural network (HNN) estimators for online, constrained parameter estimation under time‐varying data, additive disturbances, and slowly drifting physical parameters. The first is a constraint‐aware HNN that enforces linear equalities and inequalities (via slack neurons) and continuously tracks the ...
Miguel Pedro Silva
wiley   +1 more source

Atomic Scale Measurement of Polar Entropy

, 2019
Entropy is a fundamental thermodynamic quantity that is a measure of the accessible microstates available to a system, with the stability of a system determined by the magnitude of the total entropy of the system. This is valid across truly mind boggling
Alem, Nasim, Bousquet, Eric, Gopalan, Venkatraman, Miao, Leixin, Mukherjee, Debangshu, Prokhorenko, Sergei, Wang, Ke   +6 more
core   +1 more source