Results 161 to 170 of about 904,974 (305)

Distinguishing anchoring from confirmation bias in diagnostic vignette studies: methodological implications for clinical decision-making. [PDF]

Front Public Health
Martínez JA, Martínez L.
europepmc   +1 more source

Road Safety: increase in blood concentrations of cannabinoids between 2010 and 2013 – assessment of confirmation tests

, 2014
In 2008, the French government decided to set up oral-fluid drug screening in drivers. This new practice modified the customs of police officers and the number of screenings and confirming tests increased dramatically.
Gaillard, Yvan, Bévalot, Fabien, Bouvot, Xavier, Carlin, Michelle, Coste, Damien, Roussel, Olivier   +5 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Assessment of the impact of outcome definitions on power in multiple sclerosis clinical trials. [PDF]

Mult Scler J Exp Transl Clin
Li CX, Glanz BI, Baharnoori M, Healy BC.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Adherence to Underage Alcohol Sales Regulations in the Republic of Cyprus: Evidence from Repeated Cross-Sectional Mystery Shopping Study. [PDF]

Nordisk Alkohol Nark
Manoli A, Kassianos AP, Christodoulou L, Nicolaou A, Psaltis C, Michaelides M.   +5 more
europepmc   +1 more source

Confirmation Class of Immanuel Lutheran Church, Missoula, Montana

, 2013
This image shows the May 22, 1929 Confirmation Class of Immanuel Lutheran Church in Missoula, Montana. Shown standing (l-r) are: Raymond Larson, Neil Heikkila, Allan Sampson, William Strothman, Kenneth Ackerlund, Lester Willcox, and Raymond Lakey.

core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Goldberg-Shprintzen Megacolon Syndrome Diagnosed in the Neonatal Period: A Case Report With Molecular Confirmation. [PDF]

Cureus
Papaioannou E, Anastasiadou E.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source