Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Mindful diagnostics in culture-negative endocarditis: early noninvasive diagnosis of <i>Tropheryma whipplei</i> by plasma microbial cell-free DNA. [PDF]
Jain A +8 more
europepmc +1 more source
RETRACTION: Parallel Declines in Abundance of Insects and Insectivorous Birds in Denmark Over 22 Years. [PDF]
europepmc +1 more source
Beyond Visual Consensus: Tiered Reference Framework for AI Cystoscopy Studies. [PDF]
Bayraktar AM, İşler B.
europepmc +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Dispatcher-led triage to reduce futile EMS transport for suspected out-of-hospital cardiac arrest in Japan: a narrative review and phased implementation framework. [PDF]
Ito Y, Inaba H.
europepmc +1 more source
Confirmation of Exome Sequencing Results Using Sanger Sequencing-Considerations in a Low-Resource Setting. [PDF]
Louw N +10 more
europepmc +1 more source
Confirmation# 23769058 from Red Lion Hotel Seattle Airport for John Hatheway ** Do Not Reply **
confirmation@redlion.com
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