Results 71 to 80 of about 508,340 (285)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Partner rotation or extended rotations? The effect of confirmation bias and motivated reasoning bias on objectivity and independence: A framework

Journal of Global Business Insights, 2019
We propose a two-dimensional audit rotation framework on auditors’ rotation that contributes to the discussion on the potential impact of alternatives to strengthen and maintain unbiased attitude, objectivity, and independence.
Lei Dong, Robert Sarikas, Arsen Djatej
doaj   +1 more source

Electronic and thermal sequential transport in metallic and superconducting two-junction arrays

, 2011
The description of transport phenomena in devices consisting of arrays of tunnel junctions, and the experimental confirmation of these predictions is one of the great successes of mesoscopic physics.
A.B. Zorin, A.J. Manninen, A.J. Manninen, A.N. Korotkov, D.V. Averin, D.V. Averin, F. Giazotto, G.-L. Ingold, G.S. Paraoanu, H. Houten van, J. Bardeen, J.G. Simons, J.J. Toppari, J.J. Toppari, J.P. Pekola, J.P. Pekola, M.G. Blamire, M.H. Devoret, M.M. Leivo, P. Törmä, P.J. Koppinen, R.C. Dynes, R.J. Schoelkopf, S. Kafanov, W.A. Harrison, W.A. Hofer, Y. Nakamura, Y.T. Tan   +27 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Opinion Cascades and Echo-Chambers in Online Networks: A Proof of Concept Agent-Based Model [PDF]

, 2016
In online networks, the polarization of opinions (e.g., regarding presidential elections or referenda) has been associated with the creation of “echo-chambers” of like-minded peers, secluded from those of contrary viewpoints.
Anette Buyken (163185), Berthold Koletzko (144194), Carl-Peter Bauer (163155), Carla Harris (3548480), Claudia Flexeder (412834), Dietrich Berdel (163164), Elisabeth Thiering (487474), Irene BrĂźske (3548483), Marie Standl (163136), Sibylle Koletzko (163151)   +9 more
core   +3 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Collective Josephson vortex dynamics in a finite number of intrinsic Josephson junctions

, 2006
We report the experimental confirmation of the collective transverse plasma modes excited by the Josephson vortex lattice in stacks of intrinsic Josephson junctions in Bi$_{2}$Sr$_{2}$CaCu$_{2}$O$_{8+x}$ single crystals.
Bae, Myung-Ho, Choi, Jae-Hyun, Lee, Hu-Jong   +2 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Statistical Significance Filtering Overestimates Effects and Impedes Falsification: A Critique of Endsley (2019)

Frontiers in Psychology, 2020
Whether in meta-analysis or single experiments, selecting results based on statistical significance leads to overestimated effect sizes, impeding falsification.
Jonathan Z. Bakdash, Jonathan Z. Bakdash, Laura R. Marusich, Jared B. Kenworthy, Elyssa Twedt, Erin G. Zaroukian   +5 more
doaj   +1 more source