Results 171 to 180 of about 158,010 (251)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Correction to "Adaptation and Validation of the Indonesian Version of the Problem Areas in Diabetes Scale Among People With Type 2 Diabetes: An Exploratory and Confirmatory Factor Analysis". [PDF]

Nurs Open
europepmc   +1 more source

Translation, Reliability, Psychometric Validation, and Confirmatory Factor Analysis of the Urdu Version of the Self-Efficacy for Appropriate Medication Use Scale (SEAMS-U) Among Hypertensive Patients in Lahore, Pakistan: A Validation Study. [PDF]

Health Sci Rep
Arshed M, Kiran M, Raashed M, Umar A, Lone SB, Qamer S, Yaqoob M, Kripalani S, Zofeen S, Iqbal S, Ahmad S, Umer MF.   +11 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Confirmatory factor analysis of competing PANSS negative symptom models: data from OPTiMiSE first-episode schizophrenia study. [PDF]

BJPsych Open
Demjaha A, Stahl D, Arango C, Glenthøj B, Rodriguez-Jimenez R, Díaz-Caneja CM, Baandrup L, Ebdrup B, Paz Garcia-Portlla M, Diaz-Marsa M, Winter-van Rossum I, Kahn R, Dazzan P, McGuire P.   +13 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Estimating the minimal important change of single-item measures using the adjusted predictive modeling method or the longitudinal confirmatory factor analysis method. [PDF]

Qual Life Res
Terluin B, Pua YH, Fromy P, Trigg A, van der Zwaard B, Bjorner JB.   +5 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Psychometric Evaluation of the Pittsburgh Sleep Quality Index in Korean Breast Cancer Survivors: A Confirmatory Factor Analysis. [PDF]

Healthcare (Basel)
Jung MS, Park M, Cha K, Cui X, Lee AR, Hwang J.   +5 more
europepmc   +1 more source