Results 51 to 60 of about 4,195,887 (419)
A modified weighted log-rank test for confirmatory trials with a high proportion of treatment switching [PDF]
, 2020 In confirmatory cancer clinical trials, overall survival (OS) is normally a primary endpoint in the intention-to-treat (ITT) analysis under regulatory standards. After the tumor progresses, it is common that patients allocated to the control group switch to the experimental treatment, or another drug in the same class.
arxiv +1 more source
A validity and reliability study of the Attitudes toward Sustainable Development scale [PDF]
, 2016 This article describes the development and validation of the Attitudes toward Sustainable Development scale, a quantitative 20-item scale that measures Italian university students\u2019 attitudes toward sustainable development.
Biasutti, Michele, Frate, Sara
core +1 more source
The dual nature of TDC – bridging dendritic and T cells in immunity
FEBS Letters, EarlyView.TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source
Evaluating the validity of a German translation of an uncanniness questionnaire [PDF]
arXiv, 2023 When researching on the acceptance of robots in Human-Robot-Interaction the Uncanny Valley needs to be considered. Reusable and standardized measures for it are essential. In this paper one such questionnaire got translated into German. The translated indices got evaluated (n=140) for reliability with Cronbach's alpha.
arxiv
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
FEBS Letters, EarlyView.Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard +7 more
wiley +1 more source
Exploratory and confirmatory factor analysis of digital entrepreneur skills [PDF]
Problems and Perspectives in ManagementResearch in the field of entrepreneurship has become an intriguing area for further investigation. In an era where digital advancements are ubiquitous, previous researchers have identified a gap: the lack of a specific instrument to identify digital ...
Chairul Huda Atma Dirgatama
doaj +1 more source
Fairness in classroom assessment: development and validation of a questionnaire
Language Testing in Asia, 2022 Although fairness in assessment practices has gained noticeable attention over the recent years, there has been a long-lasting study to design and validate a questionnaire to measure it from a psychometric perspective.
Afsheen Rezai
doaj +1 more source
Are the Signs of Factor Loadings Arbitrary in Confirmatory Factor Analysis? Problems and Solutions [PDF]
Structural Equation Modeling: A Multidisciplinary Journal 2024The replication crisis in social and behavioral sciences has raised concerns about the reliability and validity of empirical studies. While research in the literature has explored contributing factors to this crisis, the issues related to analytical tools have received less attention.
arxiv +1 more source