Results 161 to 170 of about 41,310 (256)

Development and validation of the gynecologic examination anxiety scale (GEAS): A 20‐item patient‐reported measure

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Gynecologic examinations often provoke anxiety, embarrassment, and a perceived loss of control. Valid, patient‐focused tools that specifically quantify examination‐related anxiety remain limited. This study developed and validated the gynecologic examination anxiety scale (GEAS). Methods In a methodological study conducted in Turkey (
Hacer Demirtop   +2 more
wiley   +1 more source

Integrative host–microbiome modeling uncovers the implication of oral–gut translocation in advanced cirrhosis

open access: yesiMeta, EarlyView.
Liver cirrhosis is associated with profound disruption of host–microbiome metabolic interactions. Using paired oral and fecal metagenomics combined with genome‐scale metabolic modeling, we investigated how microbial translocation along the oral–gut axis influences microbial metabolism at different cirrhosis severities.
Yi Jin   +21 more
wiley   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

open access: yesInterdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang   +10 more
wiley   +1 more source

A multidimensional biomarker model of vitality and its associations with intrinsic capacity and frailty. [PDF]

open access: yesJ Nutr Health Aging
Chew J   +7 more
europepmc   +1 more source

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

open access: yesInterdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang   +3 more
wiley   +1 more source

Between Dependence and Alienation: Understanding the Digital Minimalist Behavior of Chinese Millennials—An Analysis Based on SEM and fsQCA

open access: yesJournal of Adolescence, EarlyView.
ABSTRACT Introduction Following rapid iterations in media technologies, Chinese millennials (born between 1980 and 1995) find themselves in a paradoxical state where digital saturation exists alongside fatigue, making them central practitioners of digital minimalist behavior.
Chao Zhang, Yinze Hao, Jingwen Li
wiley   +1 more source

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