Results 91 to 100 of about 3,411,061 (276)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Conflict of Interest in the Global Information Network.(Parties, Interests and Conflicts)

, 2021
Every professional who professionally approaches the global information space in addition to being a participant in the processes taking place in this space is also a witness to constant social problems Especially in the event of a ...
Aygun Alieva, Hicran Zeynalova, Kazimi Parviz Firudin Oqlu   +2 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

An Efficiency-Based Approach to Disclosing Expert Witnesses' Conflict of Interest in International Commercial Arbitration under English Law

, 2023
Disclosing conflict of interest by expert witnesses is an important feature of international commercial arbitration. Failure to disclose or untimely disclosure of conflict of interest by expert witnesses can adversely affect the arbitral process and spur
Okoli, Pontian
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Professional Responsibility and Conflict of Interest [PDF]

Studia Gilsoniana, 2017
When conflicts of interests arise for the professional, s/he should be aided in their resolution by a long-standing body of knowledge called ethics. Ethics provides an array of concepts, vocabulary, and strategies to aid in both the understanding and the
Lois Eveleth
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Academic conflict of interest

, 2018
PURPOSE: We set out to summarize the current challenges in academic conflict of interest. METHODS: This is a narrative review by a multidisciplinary, multinational panel of academic officers including deans of medical/pharmacy schools.
N. Lerolle, K.M. Olsen, Annane, Djillali, Olsen, Keith K.M., Sibilla, Jean, Olsen, Keith, D. Annane, Meuris, Sylvain, S. Meuris, J. Sibilla, Lerolle, Nicolas   +10 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Prohibiting or 'Managing' Conflict of Interest? A Review of Policies and Procedures in Three European Drug Regulation Agencies

, 2010
In light of debates about the relationship between interests and scientific expert judgments, and the potential for declarations of conflict of interest (COI) to minimize corporate bias, we reviewed the approach to COI in 3 European drug regulatory ...
Lexchin, Joel, O'Donovan, Orla
core   +1 more source