Results 41 to 50 of about 5,853,531 (371)

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

STRESS TESTING IS AN IMPORTANT DIAGNOSTIC TOOL IN DETECTING CORONARY ARTERY DISEASE

Gomal Journal of Medical Sciences, 2015
Among many other causes of death, cardiovascular disease is the most common cause of death in developing countries including Pakistan. Management strategies for cardiovascular disease are constantly developing.
Muhammad Inam Qureshi, Afzal Qasim, Darshan kumar, Muhammad Umar Khan   +3 more
doaj  

Classical and quantum: a conflict of interest

, 2017
We highlight three conflicts between quantum theory and classical general relativity, which make it implausible that a quantum theory of gravity can be arrived at by quantising classical gravity.
A Bassi, A Bassi, A Frenkel, A Frenkel, A Kent, A Vinante, AO Caldeira, B Collett, B Vacchini, C Anastapoulos, D Bohm, D Bohm, D Bohm, D Deutsch, D Dürr, D Dürr, D Dürr, D Giulini, D Giulini, D Giulini, D Wallace, DS DeWitt, E Joos, E Joos, F Karolyhazy, GC Ghirardi, GC Ghirardi, H Everett III, H Putnam, HD Zeh, HP Breuer, J Bub, JA Wheeler, K Hornberger, K Lochan, K Lochan, L Diósi, L Diósi, L Diósi, M Bahrami, M Bahrami, M Brune, M Schlosshauer, M Schlosshauer, M Tegmark, P Pearle, PR Holland, R Harrison, R Harrison, R Penrose, R Penrose, R Ruffini, RA Harris, S Bera, S Bera, S Bera, S Gerlich, SL Adler, SL Adler, SL Adler, SL Adler, SL Adler, WH Zurek, WH Zurek   +63 more
core   +1 more source

Task-switch costs subsequent to cue-only trials [PDF]

, 2017
Acknowledgements The authors would like to thank Fiona Carr, Carmen Horne, and Brigitta Toth for assistance with data collection. Disclosure statement No potential conflict of interest was reported by the authors.
Martin, Douglas, Prosser, Laura Joy, Swainson, Rachel   +2 more
core   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Post-Employment, “Revolving Door,” Laws for Federal Personnel [PDF]

, 2014
[Excerpt] Conflict of interest regulations and restrictions on certain private employment opportunities for a federal officer or employee do not necessarily end with the termination of the officer’s or employee’s federal service.
Maskell, Jack
core   +2 more sources

Mediation in Situations of Conflict and Limited Commitment [PDF]

, 2004
We study the reasons and conditions under which mediation is beneficial when a principal needs information from an agent to implement an action. Assuming a strong form of limited commitment, the principal may employ a mediator who gathers information and
Mitusch, Kay, Strausz, Roland
core   +2 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source