Results 61 to 70 of about 5,971,609 (331)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

L’inconduite en recherche engendrée par l’intérêt personnel: comment gérer une telle situation?

open access: yesBioéthiqueOnline, 2013
This fictional case study illustrates how the results of certain research projects can be used in order to serve personal interests, leading to scientific research misconduct.
Haidar, Hazar
doaj  

Creditor's (conflict of) interest during the bankruptcy proceeding [PDF]

open access: yes
Nowadays we are living in the golden age of involuntary dissolutions of companies . Starting from the liquidations’ statistics, the role of the reorganization keeps growing.
Anna Francsovics, Zsuzsa Piller
core  

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

CONFLICT OF INTEREST IN ADMINISTRATIVE LAW [PDF]

open access: yesChallenges of the Knowledge Society, 2017
We are currently witnessing, on the one hand, new forms of relationships between public and private sector, such as public-private partnership agreements, concession agreements, etc.
Elena Emilia ȘTEFAN
doaj  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

CONFLICT OF INTEREST: A CRITICAL ANALYSIS OF FRANCHISING BUSINESS [PDF]

open access: yes
There are many multinational companies engaging with the franchising mechanisms in order to expand the business opportunity, to explore new opportunities, and to develop businesses domestically and internationally.
Hassanudin Bin Mohd Thas Thaker
core  

Conflict-Free Coloring of Intersection Graphs of Geometric Objects

open access: yes, 2017
In FOCS'2002, Even et al. introduced and studied the notion of conflict-free colorings of geometrically defined hypergraphs. They motivated it by frequency assignment problems in cellular networks. This notion has been extensively studied since then. A
Keller, Chaya, Smorodinsky, Shakhar
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Physicians-Pharmaceutical Sales Representatives Interactions and Conflict of Interest

open access: yesInquiry : a journal of medical care organization, provision and financing, 2016
Physician-industry relationships have come a long way since serious debates began after a 1990 Senate Committee on Labor and Human Resources report on the topic.
Avinash Patwardhan
semanticscholar   +1 more source

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