Results 41 to 50 of about 1,936 (189)

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Comparative Transcriptional Profiling of Key Macrophage and Fibroblast Subpopulations in Rheumatoid Arthritis–Associated Lung Disease

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) often involves extra‐articular complications, including interstitial lung disease (ILD) and/or pulmonary nodules. Transcriptomic profiling of lung tissue provides the opportunity to directly assess cell‐specific gene expression and corresponding pathway activation in different types of rheumatoid lung disease ...
Tracy Tabib, Ogechukwu Ezenwa, Joshua Sciurba, Eleanor B. Valenzi, John Sembrat, Brittany Cody, Jishnu Das, Robert Lafyatis, Dana P. Ascherman   +8 more
wiley   +1 more source

Properties of Matrix Variate Beta Type 3 Distribution

International Journal of Mathematics and Mathematical Sciences, 2009
We study several properties of matrix variate beta type 3 distribution. We also derive probability density functions of the product of two independent random matrices when one of them is beta type 3.
Arjun K. Gupta, Daya K. Nagar
doaj   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Bazi Bushen Capsule restores fertility by targeting mitochondrial health in aging endometrium

iMeta, EarlyView.
Bazi Bushen Capsule (BZBS) mitigates age‐related endometrial dysfunction by activating AMPK − SIRT3 signaling. Luteolin, a key bioactive component, restores mitochondrial homeostasis via PINK1/Parkin−mediated mitophagy and Drp1 inhibition, improving endometrial function and fertility potential.
Shangqi Li, Feng Deng, Hongjuan Niu, Meng Li, Zeyang Lin, Jiayi Ma, Yue Wang, Yueqi Leng, Yunlong Hou, Wenwen Cui, Yang Yu, Heng Pan, Ping Zhou, Rong Li   +13 more
wiley   +1 more source

Differential Myopathic and Transcriptomic Changes in Soleus and Gastrocnemius Muscles in a Novel Chronic Hindlimb Ischemia Rat Model Induced by Endovascular Catheter Occlusion

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Peripheral artery disease (PAD) is a progressive atherothrombotic disorder affecting more than 230 million people worldwide. Conventional animal models of chronic hindlimb ischemia (HLI) are highly invasive, technically challenging, fail to account for anatomical variation, and may not accurately recapitulate progressive PAD pathophysiology ...
Oliver Kitzerow, Zhiqiu Xia, Samuel Gillman, Iraklis I. Pipinos, Han‐Jun Wang   +4 more
wiley   +1 more source

On the Matrix Versions of Incomplete Extended Gamma and Beta Functions and Their Applications for the Incomplete Bessel Matrix Functions

Complexity, 2021
In this paper, we first introduce the incomplete extended Gamma and Beta functions with matrix parameters; then, we establish some different properties for these new extensions. Furthermore, we give a specific application for the incomplete Bessel matrix
Chaojun Zou, Mimi Yu, Ahmed Bakhet, Fuli He   +3 more
doaj   +1 more source

Investigating GERMs: how genotype, environment, and rhizosphere microbiome interactions underlie heat response in maize and sorghum

New Phytologist, Volume 251, Issue 4, Page 2152-2167, August 2026.
Three genotypes – a heat‐resistant maize (Zea mays), a heat‐susceptible maize, and a sorghum (Sorghum bicolor) variety – were grown to the V4 stage in growth chambers under optimal conditions or subjected to heat stress. Plants were grown in soil containing a complex microbial community, or in the same soil with a depleted microbiome.
Nate Korth, Isabella Borrero, Katelyn Rumley, Alex L. Woodley, Mallory J. Choudoir, Joseph L. Gage   +5 more
wiley   +1 more source

Development of parallel computing algorithms for special mathematical functions in fractional calculus: Implementation with GPU and CUDA

Results in Engineering
This work presents the development of parallel computing algorithms for special mathematical function used in fractional calculus. A systematic and step-by-step procedure is proposed for parallelization of computation of Gamma function, 1-, 2-, 3-, and 4-
Chaitanya S. Jage, Vishwesh A. Vyawahare, Mukesh D. Patil   +2 more
doaj   +1 more source

An Extension of Wright Function and Its Properties

Journal of Mathematics, 2015
The paper is devoted to the study of the function Wα,βγ,δ(z), which is an extension of the classical Wright function and Kummer confluent hypergeometric function.
Moustafa El-Shahed, Ahmed Salem
doaj   +1 more source