Results 201 to 210 of about 180,806 (263)

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Interferometric Image Scanning Microscopy for label-free imaging at 120 nm lateral resolution inside live cells. [PDF]

Light Sci Appl
Küppers M, Moerner WE.
europepmc   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

In vitro assessment of experimental bioactive tooth gel formulas containing L-arginine, ginger and eggshell for remineralization and anti-bacterial effect. [PDF]

Sci Rep
Saleh RS, El-Hashemy HA, Elgamily HM.
europepmc   +1 more source

Nanoscale Localization Microscopy and Deterministic Lithography of Solid-State Quantum Emitters. [PDF]

ACS Photonics
Bishop SG, Yağcı HB, Clark RN, Hadden JP, Bennett AJ.   +4 more
europepmc   +1 more source

The Penetration Depth and Bactericidal Efficacy of 2% Chlorhexidine Iontophoresis in Human Coronal Dentin In Vitro. [PDF]

Int Dent J
Kijsamanmith K, Satitthummanit N, Thotsaphonphaisan C, Kurucharoenporn C, Ratarsa T, Lerdmaneepha V, Kanchanathipkhachorn N, Klaophimai A, Srisatjaluk R.   +8 more
europepmc   +1 more source

The UBC/SIRT5/DRP1 axis regulates mitochondrial dynamics to alleviate Staphylococcus aureus-induced oxidative stress and senescence in bovine mammary epithelial cells. [PDF]

PLoS Pathog
Hu H, Jiang N, Liu J, Bi J, Liu X, Xu B, Cao Y, Guo W, Fu S.   +8 more
europepmc   +1 more source

Identification of heat-treated lithic artifacts via quantitative surface gloss characterization. [PDF]

Sci Rep
Stárek R, Sahle Y, Atnafu B, Moník M.
europepmc   +1 more source

Probing individual quantum emitters in bulk semiconductors via photonic nanojets. [PDF]

Sci Adv
Semnani B, Venuturumilli SS, Soltani M, Adhikary P, Pasharavesh A, Videnov N, Anderson P, Sarkar S, Muthu VRR, Bajcsy M.   +9 more
europepmc   +1 more source

How the Confocal Laser Scanning Microscope entered Biological Research [PDF]

Biology of the Cell, 2003
AbstractA history of the early development of the confocal laser scanning microscope in the MRC Laboratory of Molecular Biology in Cambridge is presented. The rapid uptake of this technology is explained by the wide use of fluorescence in the 80s. The key innovations were the scanning of the light beam over the specimen rather than vice‐versa and a ...
W B Amos, J G White
exaly   +3 more sources