Results 41 to 50 of about 415,132 (338)

Confocal Microscopy in Skin Cancer [PDF]

Current Dermatology Reports, 2011
Reflectance confocal microscopy (RCM) enables imaging of skin lesions at cellular level resolution at the bedside (in vivo) or in freshly excised tissue (ex vivo). This article provides an overview of strengths and limitations of non-invasive RCM in skin cancer diagnosis.RCM features of common melanocytic and non-melanocytic skin neoplasms such as ...
Margaret Oliviero, Verena Ahlgrimm-Siess, Rainer Hofmann-Wellenhof, Ashfaq A. Marghoob, Martin Laimer, Harold S. Rabinovitz, Alon Scope   +6 more
openaire   +4 more sources

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Deep-3D Microscope: 3D volumetric microscopy of thick scattering samples using a wide-field microscope and machine learning [PDF]

arXiv, 2021
Confocal microscopy is the standard approach for obtaining volumetric images of a sample with high axial and lateral resolution, especially when dealing with scattering samples. Unfortunately, a confocal microscope is quite expensive compared to traditional microscopes.
arxiv  

Accessible quantitative phase imaging in confocal microscopy with sinusoidal-phase synthetic optical holography [PDF]

Applied Optics 58 (2019), pp A55-A64, 2019
We present a technically simple implementation of quantitative phase imaging in confocal microscopy based on synthetic optical holography with sinusoidal-phase reference waves. Using a Mirau interference objective and low-amplitude vertical sample vibration with a piezo-controlled stage, we record synthetic holograms on commercial confocal microscopes (
arxiv   +1 more source

Fluorescence confocal microscopy for pathologists [PDF]

Modern Pathology, 2014
Confocal microscopy is a non-invasive method of optical imaging that may provide microscopic images of untreated tissue that correspond almost perfectly to hematoxylin- and eosin-stained slides. Nowadays, following two confocal imaging systems are available: (1) reflectance confocal microscopy, based on the natural differences in refractive indices of ...
Ragazzi M., Piana S., Longo C., Castagnetti F., Foroni M., Ferrari G., Gardini G., Pellacani G.   +7 more
openaire   +5 more sources

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Confocal microscopy in the diagnosis of melanoma [PDF]

Archives of Biological Sciences, 2013
Melanoma is the most deadly form of skin cancer of melanocytic origin. The tumor has a high malignant potential and early metastasis. Prognosis is directly linked to the stage of the disease.
Apostolović-Stojanović Milica, Dobrosavljević-Vukojević Danijela, Lačković Vesna, Stojanović A., Marković I., Džodić R.   +5 more
doaj   +1 more source

The Quest for Early Detection of Retinal Disease: 3D CycleGAN-based Translation of Optical Coherence Tomography into Confocal Microscopy [PDF]

Biol. Imaging 4 (2024) e15
Optical coherence tomography (OCT) and confocal microscopy are pivotal in retinal imaging, offering distinct advantages and limitations. In vivo OCT offers rapid, non-invasive imaging but can suffer from clarity issues and motion artifacts, while ex vivo confocal microscopy, providing high-resolution, cellular-detailed color images, is invasive and ...
arxiv   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source