Results 41 to 50 of about 718,486 (322)

Methods to calibrate and scale axial distances in confocal microscopy as a function of refractive index

, 2014
Accurate distance measurement in 3D confocal microscopy is important for quantitative analysis, volume visualization and image restoration. However, axial distances can be distorted by both the point spread function and by a refractive-index mismatch ...
Besseling, Thijs Herman, Jose, Jissy, van Blaaderen, Alfons   +2 more
core   +1 more source

Characterization of Laser-Resistant Port Wine Stain Blood Vessels Using In Vivo Reflectance Confocal Microscopy. [PDF]

, 2019
Background and objectivesPort wine stain (PWS) is a congenital vascular malformation of the human skin. Laser is the treatment of choice for PWS. Laser-resistant PWS is one crucial factor accounting for inadequate treatment outcome, which needs to be ...
Chen, Jing, Fu, Zhibing, Huang, Jian, Huang, Jinhua, Lu, Jianyun, Nelson, J Stuart, Tan, Wenbin, Tang, Zhen, Xiang, Yaping   +8 more
core   +1 more source

Reflectance Confocal Microscopy of Skin after the Sting of the Jellyfish Pelagia noctiluca

Case Reports in Dermatology, 2023
Jellyfish are aquatic animals of the phylum Cnidaria found in seas all over the world. They are characterized by the presence of cnidocytes, cells that contain a secretory organelle, the cnidocyst, mainly used for predation and defense purposes. An adult
Giovanni Paolino, Matteo Riccardo Di Nicola, Riccardo Pampena, Vittoria Giulia Bianchi, Santo Raffaele Mercuri   +4 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

CD3+CD4+LAP+Foxp3-regulatory cells of the colonic lamina propria limit disease extension in ulcerative colitis [PDF]

, 2018
Background and Aims: In ulcerative colitis (UC), inflammation begins in the rectum and can extend proximally throughout the entire colon. The extension of inflammation is an important determinant of disease course, and may be limited by the action of ...
Amendola, Antonello, Boirivant, Monica, Borrini, Francesco, Butera, Alessia, De Nitto, Daniela, Di Carlo, Nazzareno, Frasca, Loredana, Lande, Roberto, Pica, Roberta, Pronio, Annamaria, Sanchez, Massimo   +10 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Deep Transfer Learning Methods for Colon Cancer Classification in Confocal Laser Microscopy Images

, 2019
Purpose: The gold standard for colorectal cancer metastases detection in the peritoneum is histological evaluation of a removed tissue sample. For feedback during interventions, real-time in-vivo imaging with confocal laser microscopy has been proposed ...
Bengs, Marcel, Drömann, Daniel, Ellebrecht, David B., Gessert, Nils, Keck, Tobias, Schlaefer, Alexander, Wittig, Lukas   +6 more
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Super-resolution microscopy reveals glioma cell footprints and exosome deposits

Cell Adhesion & Migration
Gliomas are aggressive brain tumors whose infiltrative growth is mediated by intercellular crosstalk. Exosomes, small extracellular vesicles, play a key role in cell–cell communication but are difficult to visualize using conventional microscopy ...
Stefania Petrini, Frédéric Eghiaian, Valentina Apollonio, Giulia Pericoli, Maria Vinci   +4 more
doaj   +1 more source

Intratumoral Cancer Cell Intravasation Can Occur Independent of Invasion into the Adjacent Stroma

Cell Reports, 2017
Summary: Intravasation, active entry of cancer cells into the circulation, is often considered to be a relatively late event in tumor development occurring after stromal invasion. Here, we provide evidence that intravasation can be initiated early during
Elena I. Deryugina, William B. Kiosses
doaj   +1 more source