Results 81 to 90 of about 718,486 (322)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Optical Aberrations and Objective Choice in Multicolor Confocal Microscopy

BioTechniques, 2000
Refinements in design have simplified confocal microscopy to the extent that it has become a standard research tool in cell biology. However, as confocal microscopes have become more powerful, they have also become more demanding of their optical ...
Kenneth W. Dunn, Exing Wang
doaj   +1 more source

Microscopy study of ripples created on steel surface by use of ultra short laser pulses [PDF]

, 2010
This paper concentrates on ripples on the surface of steel that arise from lasermaterial interaction. In particular we have observed two different sets of ripples on steel samples that were machined by 210 fs laser pulses with 800 nm wavelength at normal
Hosson, J.Th.M. de, Huis in 't Veld, A.J., Mitko, V.S., Ocelik, V., Römer, G.R.B.E., Skolski, J.Z.P., Vincenc Obona, J., Visser, B.   +7 more
core   +1 more source

Reflection confocal nanoscopy using a super-oscillatory lens [PDF]

, 2019
A Superoscillatory lens (SOL) is known to produce a sub-diffraction hotspot which is useful for high-resolution imaging. However, high-energy rings called sidelobes coexist with the central hotspot.
Achanta, Venu Gopal, Bäumer, Stefan M. B., Gerini, Giampiero, Nagarajan, Arvind, Siemons, Marijn, Silvestri, Fabrizio, Stoevelaar, L. Pjotr   +6 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Clinical applications of corneal confocal microscopy

Clinical Ophthalmology, 2008
Mitra Tavakoli1, Parwez Hossain2, Rayaz A Malik11Division of Cardiovascular Medicine, University of Manchester and Manchester Royal Infirmary, Manchester, UK; 2University of Southampton, Southampton Eye Unit, Southampton General Hospital, Southampton ...
Mitra Tavakoli, Parwez Hossain, Rayaz A Malik   +2 more
doaj  

Combining confocal and BSE SEM imaging for bone block surfaces [PDF]

, 2005
The present report presents a method for the correlation of qualitative and quantitative BSE SEM imaging with confocal scanning light microscopy (CSLM) imaging modes applied to bone samples embedded in PMMA.
Boyde, A, Lovicar, L, Zamecnik, J
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Análise invasiva e não invasiva do fuso meiótico de oócitos humanos obtidos de ciclos estimulados: dados preliminares Invasive and noninvasive analysis of the meiotic spindle of human oocytes obtained from stimulate cycles: preliminary results

Revista Brasileira de Ginecologia e Obstetrícia, 2012
OBJETIVOS: Avaliar a concordância entre as técnicas de microscopia de polarização e microscopia confocal na avaliação do fuso meiótico de oócitos humanos maturados in vivo.
Luciana Azôr Dib, Michele Gomes da Broi, Maria Cristina Picinato Medeiros de Araújo, Roberta Cristina Giorgenon, Rui Alberto Ferriani, Paula Andrea de Albuquerque Sales Navarro   +5 more
doaj   +1 more source