Results 211 to 220 of about 137,560 (275)

A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control

open access: yesAdvanced Science, EarlyView.
Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias   +23 more
wiley   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

open access: yesAdvanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao   +12 more
wiley   +1 more source

Basal Plane Graphene Coated Zn Powder for High Performance Aqueous Zn Metal Batteries

open access: yesAdvanced Science, EarlyView.
A mechanofusion‐driven dry coating forms a hydrophobic graphene shell on Zn powder, stabilizing the electrode‐electrolyte interface. This basal‐plane‐rich protective layer modifies the Zn2+ solvation environment and promotes preferential growth along the (002) plane, suppressing dendrite and parasitic reactions.
Dongju Kim   +8 more
wiley   +1 more source

Conformal invariance of multiple integrals in the calculus of variations

open access: yesJournal of Mathematical Analysis and Applications, 1974
openaire   +1 more source

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

open access: yesAdvanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu   +14 more
wiley   +1 more source

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