Results 131 to 140 of about 37,668 (284)

The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening

Advanced Science, EarlyView.
A novel method for the preparation of uniform microspheric skin organoids via spinning bioreactors is developed. The organoid consists of a core‐shell structure to mimic the bilayered skin structure with the epidermis on the surface. For efficient drug screening, the organoid is equipped with a luciferase reporter to detect canonical Wnt signaling, and
Jundong Xie, Qingyang Yang, Yanan Zhang, Ke Zheng, Hongya Geng, Yaojiong Wu   +5 more
wiley   +1 more source

The State of High‐Resolution Imaging of the Human Inner Ear: A Look Into the Black Box

Advanced Science, EarlyView.
High‐resolution imaging of the cochlea is challenged by numerous unique aspects of this organ, where sensorineural cells, crucial for hearing, are too small for conventional modalities like magnetic resonance imaging and computed tomography. This article reviews current imaging techniques, emerging technologies, and innovations aimed at improving ...
Shelley Batts, Nancy Pham, Guillermo Tearney, Konstantina M. Stankovic   +3 more
wiley   +1 more source

Transient Interdomain Interactions Modulate the Monomeric Structural Ensemble and Self‐Assembly of Huntingtin Exon 1

Advanced Science, EarlyView.
Polyglutamine (polyQ) tract expansion (≥ 36 amino acids) within the N‐terminal region of the Huntingtin protein (Httex1) causes Huntington's disease (HD), for which the underlying causes are not well‐understood. The authors performed computer simulations to understand the cause of HD at the molecular level.
Priyesh Mohanty, Tien Minh Phan, Jeetain Mittal   +2 more
wiley   +1 more source

A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines.
Laura Bindila, Tore Eid, James D. Mills, Michael S. Hildebrand, Gary P. Brennan, Susan A. Masino, Vicky Whittemore, Piero Perucca, Christopher A. Reid, Manisha Patel, Kevin K. Wang, Erwin A. van Vliet   +11 more
wiley   +1 more source

Design of Fractional Order Sliding Mode Controller for Chaos Suppression of Atomic Force Microscope System

Iranian Journal of Electrical and Electronic Engineering, 2019
A novel nonlinear fractional order sliding mode controller is proposed to control the chaotic atomic force microscope system in presence of uncertainties and disturbances. In the design of the suggested fractional order controller, conformable fractional
S. Haghighatnia, H. Toossian Shandiz
doaj  

Enhanced Electrical Performance and Stretchability by Plasticizer‐Facilitated PEDOT:PSS Self‐Alignment

Advanced Science, EarlyView.
To advance stretchable electronics, understanding how organic plasticizers influence poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) morphology and conductivity remains crucial. A bilayer model with glycerol‐infused poly(vinyl alcohol) (PVA) substrates reveals that plasticizer diffusion reorganizes PEDOT and PSS, improving ...
Carla Volkert, Mateusz Brzezinski, Pablo Gomez Argudo, Renan Colucci, Sapun H. Parekh, Pol Besenius, Jasper J. Michels, Ulrike Kraft   +7 more
wiley   +1 more source

Kinetically Enhanced Access to a Dynamic Polyester Platform via Sequence Selective Terpolymerisation of Elemental Sulphur

Angewandte Chemie, EarlyView.
A rare sequence‐selective terpolymerisation of elemental sulphur, aromatic thioanhydrides, and epoxides yields dynamic poly(ester‐alt‐Sx) polymers. Mechanistic insights reveal a lithium‐catalysed rate enhancement via ester coordination. The resulting polymers are thermally stable, backbone‐editable, and processable into degradable adhesives.
Cesare Gallizioli, Peter Deglmann, Alex J. Plajer   +2 more
wiley   +2 more sources

Light‐Driven PAA Adhesive: A Green Bonding Platform Integrating High‐Performance, Environmental Resilience, and Closed‐Loop Recyclability

Advanced Science, EarlyView.
This investigation introduces the formulation of a cutting‐edge, robust polyacrylic aqueous adhesive (PAA), synthesized through the employment of visible‐light initiated polymerization. The adhesive demonstrates minimal energy demand, environmental friendliness, robust adhesive properties (20.86 MPa on wood), remarkable thermal stability (with ...
Xueying Fu, Jingtian Chen, Yuqi Zhao, Yanan Liu, Chenyang Xie, Xuhang Zhang, Yingdan Liu, Jingyue Yang   +7 more
wiley   +1 more source

Microbial Biosensor for Sensing and Treatment of Intestinal Inflammation

Advanced Science, EarlyView.
The engineered calprotectin biosensor detects gut inflammation, processes the signal through genetic regulation, and responds by expressing the reporter sfGFP and the therapeutic protein secIL10. This dual functionality enables the engineered biosensor not only to sense but also to mitigate gut inflammation, highlighting its potential for disease ...
Duolong Zhu, Jeffrey Galley, Jason Pizzini, Elena Musteata, Martin V. Douglas, Walter J. Chazin, Eric P. Skaar, Jeffrey J. Tabor, Robert A. Britton   +8 more
wiley   +1 more source

Fractional calculus in data fitting

Alexandria Engineering Journal, 2020
This paper investigates the role of fractional calculus in data fitting. We show that while the Caputo and Atangana-Baleanu fractional derivatives can be applied successfully in data fitting, this might not be true for the conformable derivative.
N.H. Can, H. Jafari, M.N. Ncube
doaj