Results 41 to 50 of about 3,420 (282)

Quantitative analysis of the effects of incorporating laser powder bed fusion manufactured conformal cooling inserts in steel moulds over four types of defects of a commercially produced injected part

Journal of Materials Research and Technology, 2023
The introduction of additively manufactured conformal cooling inserts in steel moulds for plastic injection is becoming a recommended standard. Fine adjustment of the temperatures in the mould has demonstrated potential to reduce cycle times and to ...
Joaquim Minguella-Canela, Sergio Morales Planas, Vicente César de Medina Iglesias, M. Antonia de los Santos López   +3 more
doaj   +1 more source

A Thermomechanical Analysis of Conformal Cooling Channels in 3D Printed Plastic Injection Molds

Applied Sciences, 2018
Plastic injection molding is a versatile process, and a major part of the present plastic manufacturing industry. The traditional die design is limited to straight (drilled) cooling channels, which don’t impart optimal thermal (or thermomechanical)
Suchana Akter Jahan, Hazim El-Mounayri
doaj   +1 more source

An appraisal on the sustainability payback of additively manufactured molds with conformal cooling [PDF]

, 2020
The use of Additive Manufacturing (AM) in the production of tooling for injection molding has led to the introduction of conformal cooling as an effective way to lower the cycle time of the process. As the cooling cycle is responsible for a large portion
Priarone, Paolo C., Centea, Dan, Davis, William, Lunetto, Vincenzo, Settineri, Luca   +4 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Optimizing Laser Sintering Parameters and Cooling Channel Designs for Enhanced Injection Molding of Medical Tube Connectors

Journal of Applied Science and Engineering
Respiratory equipment disconnections in hospitals pose severe risks, including hypoxia and mortality. Suboptimal tube connector quality, often worsened by traditional cooling mold designs, results in uneven thermal equilibrium, product deformation, and ...
Ding Yang Hsu
doaj   +1 more source

Design and additive manufacturing of novel conformal cooling molds

Materials & Design, 2020
Additive manufacturing (AM) offers high-freedom in the design and processing of components with complex internal structures. In this work, a new injection mold with the self-supporting large cooling channel and tailored porous structures was designed to ...
Chaolin Tan, Di Wang, Wenyou Ma, Yaorong Chen, Shijin Chen, Yongqiang Yang, Kesong Zhou   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Structural Analysis of Molds with Conformal Cooling Channels: A Numerical Study

Engineering Proceedings, 2023
This article presents noteworthy discoveries pertaining to molds, featuring innovative conformal cooling channel designs. The aim of this study is to determine the upper limit of pressure that the components can endure in a real-world injection molding ...
Hugo Miguel Silva, João Tiago Noversa, Hugo Luís Rodrigues, Leandro Fernandes, António José Pontes   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source