Results 101 to 110 of about 90,774 (312)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Conformal mapping and impedance tomography
Inverse Problems, 2010 Akduman and Kress (2002 Inverse Problems 18 1659–1672), Haddar and Kress (2005 Inverse Problems 21 935–953), and Kress (2004 Math. Comput. Simul. 66 255–265) have employed a conformal mapping technique for the inverse problem to recover a perfectly conducting or a non-conducting inclusion in a homogeneous background medium from the Cauchy data on the ...
Haddar, Houssem, Kress, Rainer
openaire +5 more sources
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Arab Journal of Mathematical Sciences, 2016 In this paper, we prove that a map between Riemannian manifolds is an f-harmonic morphism in a general sense if and only if it is horizontally weakly conformal, satisfying some conditions, and we investigate the properties of f-harmonic morphism in a ...
Nour Elhouda Djaa, Ahmed Mohamed Cherif
doaj +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Virtual Mass of Any Shape of Body by using General Mapping Function
MATEC Web of Conferences, 2017 When an object is moving in acceleration with fluid interaction from surrounding, it possesses virtual mass (added mass) in which the total mass of object is higher than the original mass.
Arai Norio
doaj +1 more source
Slovak Journal of Civil Engineering, 2015 Disadvantages of the currently used Křovák’s map projection in the Slovak Republic, such as large scale distortion, became evident after the division of Czechoslovakia.
Szatmári Daniel
doaj +1 more source
Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef +10 more
wiley +1 more source
The convexity package for Hamiltonian actions on conformal symplectic manifolds
, 2019 Consider a Hamiltonian action of a compact connected Lie group on a conformal symplectic manifold. We prove a convexity theorem for the moment map under the assumption that the action is of Lee type, which establishes an analog of Kirwan's convexity ...
Chen, Youming +2 more
core
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source