Results 101 to 110 of about 90,892 (317)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Virtual Mass of Any Shape of Body by using General Mapping Function

open access: yesMATEC Web of Conferences, 2017
When an object is moving in acceleration with fluid interaction from surrounding, it possesses virtual mass (added mass) in which the total mass of object is higher than the original mass.
Arai Norio
doaj   +1 more source

The rapidly growing landscape of RAS inhibitors: from selective allele blockade to broad inhibition strategies

open access: yesMolecular Oncology, EarlyView.
RAS‐targeted therapies have become a clinical reality. Although promising results in patients have been achieved, there are still challenges ahead such as coping with drug resistance. Here we summarize selected RAS inhibitors targeting either individual KRAS mutant isoforms (KRASG12C, KRASG12D, KRASG12V) or exhibiting a wider inhibitory spectrum ...
Matthias Drosten, Mariano Barbacid
wiley   +1 more source

General f-harmonic morphisms

open access: yesArab Journal of Mathematical Sciences, 2016
In this paper, we prove that a map between Riemannian manifolds is an f-harmonic morphism in a general sense if and only if it is horizontally weakly conformal, satisfying some conditions, and we investigate the properties of f-harmonic morphism in a ...
Nour Elhouda Djaa, Ahmed Mohamed Cherif
doaj   +1 more source

Conformal maps of Carnot groups

open access: yesAnnales Academiae Scientiarum Fennicae Mathematica, 2015
If f is a conformal mapping defined on a connected open subset of a Carnot group G, then either f is the composition of a translation, a dilation and an isometry, or G is the nilpotent Iwasawa component of a real rank 1 simple Lie group S, and f arises from the action of S on G, viewed as an open subset of S/P, where P is a parabolic subgroup of G and ...
Cowling, MG, Ottazzi, A
openaire   +5 more sources

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

open access: yesFEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić   +3 more
wiley   +1 more source

The Fractional Carleson Measures on the Unit Ball of ℝn+1

open access: yesJournal of Function Spaces and Applications, 2013
We construct a quantity in terms of Lp integral of the Jacobian of a conformal self-map on the unit ball of ℝn+1. Then, we characterize the fractional Carleson measures on the unit ball by the quantity.
Dongfang Wang, Bolin Ma
doaj   +1 more source

Optimization Of Conformal Cartographic Projections For The Slovak Republic According To Chebyshev’s Theorem

open access: yesSlovak Journal of Civil Engineering, 2015
Disadvantages of the currently used Křovák’s map projection in the Slovak Republic, such as large scale distortion, became evident after the division of Czechoslovakia.
Szatmári Daniel
doaj   +1 more source

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

open access: yesFEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li   +5 more
wiley   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

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