Results 41 to 50 of about 6,532 (287)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Behavior of spatial curves under different transformations in Euclidean 4-space
Demonstratio MathematicaThis study investigates the conditions under which various curves maintain their characteristics when mapped between two regular surfaces in four-dimensional Euclidean space E4{{\mathbb{E}}}^{4}.
Badyal Pushpinder +2 more
doaj +1 more source
Dipole-magnet field models based on a conformal map
Physical Review Special Topics. Accelerators and Beams, 2012 In general, generation of charged-particle transfer maps for conventional iron-pole-piece dipole magnets to third and higher order requires a model for the midplane field profile and its transverse derivatives (soft-edge model) to high order and ...
P. L. Walstrom
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A Formula of Packing Pressure of a Factor Map
Entropy, 2017 In this paper, using the notion of packing pressure, we show a formula of packing pressure of a factor map. We also give an application in conformal repellers.
Cao Zhao +3 more
doaj +1 more source
Celestial diamonds: conformal multiplets in celestial CFT
Journal of High Energy Physics, 2021 We examine the structure of global conformal multiplets in 2D celestial CFT. For a 4D bulk theory containing massless particles of spin s = 0 1 2 1 3 2 2 $$ \left\{0,\frac{1}{2},1,\frac{3}{2},2\right\} $$ we classify and construct all SL(2,ℂ) primary ...
Sabrina Pasterski +2 more
doaj +1 more source
Notices of the American Mathematical SocietyMost conformal maps cannot be found analytically, so when computers began to appear in the 1950s and 1960s, the field of numerical conformal mapping was born. The availability of so many tools for numerical conformal mapping may suggest that the problem is easy, but in fact there are challenges.
openaire +2 more sources
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source