Results 71 to 80 of about 2,289,577 (361)

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Conformal Invariance and Stochastic Loewner Evolution Predictions for the 2D Self-Avoiding Walk - Monte Carlo Tests

open access: yes, 2003
Simulations of the self-avoiding walk (SAW) are performed in a half-plane and a cut-plane (the complex plane with the positive real axis removed) using the pivot algorithm.
Kennedy, Tom
core   +2 more sources

Hamiltonian Map to Conformal Modification of Spacetime Metric: Kaluza-Klein and TeVeS [PDF]

open access: yes, 2009
It has been shown that the orbits of motion for a wide class of non-relativistic Hamiltonian systems can be described as geodesic flows on a manifold and an associated dual by means of a conformal map.
L. Horwitz, A. Gershon, M. Schiffer
semanticscholar   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

The varieties of Heisenberg vertex operator algebras

open access: yes, 2016
For a vertex operator algebra $V$ with conformal vector $\omega$, we consider a class of vertex operator subalgebras and their conformal vectors.
Chu, Yanjun, Lin, Zongzhu
core   +1 more source

Superconformal Coset Equivalence from Level-Rank Duality [PDF]

open access: yes, 1997
We construct a one-to-one map between the primary fields of the N=2 superconformal Kazama-Suzuki models G(m,n,k) and G(k,n,m) based on complex Grassmannian cosets, using level-rank duality of Wess-Zumino-Witten models. We then show that conformal weights,
Altschüler   +35 more
core   +4 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

open access: yesFEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker   +8 more
wiley   +1 more source

A construction of conformal-harmonic maps [PDF]

open access: yesComptes Rendus. Mathématique, 2012
Conformal harmonic maps from a 4-dimensional conformal manifold to a Riemannian manifold are maps satisfying a certain conformally invariant fourth order equation. We prove a general existence result for conformal harmonic maps, analogous to the Eells-Sampson theorem for harmonic maps.
Farid Madani   +2 more
openaire   +4 more sources

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

open access: yesFEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi   +5 more
wiley   +1 more source

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