Results 51 to 60 of about 111,827 (288)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Ricci Bi-Conformal and m-Modified Conformal Vector Fields: A Study With Respect to the Riemannian Extension Metric

Journal of Mathematics
This article explores the necessary and sufficient conditions for a vector field on the cotangent bundle of a Riemannian manifold to qualify as an m− modified conformal vector field or a Ricci bi-conformal vector field.
Lokman Bilen, Aydin Gezer, Cagri Karaman
doaj   +1 more source

Conformal Symmetry and Unification

, 1998
The Weyl-Weinberg-Salam model is presented. It is based on the local conformal gauge symmetry. The model identifies the Higgs scalar field in SM with the Penrose-Chernikov-Tagirov scalar field of the conformal theory of gravity.
Pawlowski, Marek
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Pseudo-Riemannian Lie groups admitting left-invariant conformal vector fields

Comptes Rendus. Mathématique, 2020
Let $G$ be a Lorentzian Lie group or a pseudo-Riemannian Lie group of type $(n-2,2)$. If $G$ admits a non-Killing left-invariant conformal vector field, then $G$ is solvable.
Zhang, Hui, Chen, Zhiqi
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Geometry of conformal vector fields

Arab Journal of Mathematical Sciences, 2017
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysis of m-Modified Conformal Vector Fields on the Tangent Bundle With Synectic Lift Metrics

International Journal of Mathematics and Mathematical Sciences
In this study, we introduce the notion of an m-modified conformal vector field, which represents a natural generalization of the classical conformal vector field concept. This extension allows for a broader class of vector fields that conform to modified
Lokman Bilen, Erkan Karakas, Cagri Karaman, Aydin Gezer, Yanlin Li   +4 more
doaj   +1 more source

Large N analytical functional bootstrap. Part I. 1D CFTs and total positivity

Journal of High Energy Physics, 2023
We initiate the analytical functional bootstrap study of conformal field theories with large N limits. In this first paper we particularly focus on the 1D O(N) vector bootstrap.
Zhijin Li
doaj   +1 more source