Cryo-EM structures of a MexB-MexY chimeric efflux pump reveal that large open clefts are intrinsic to the MexY porter domain. [PDF]
Wang J +7 more
europepmc +1 more source
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Proline/sidechain C-H/O interactions stabilize <i>cis</i>-proline.
Oven HC, Ganguly HK, Zondlo NJ.
europepmc +1 more source
The many dimeric faces of Lys49 PLA<sub>2</sub>-like proteins: Conformational plasticity and membrane binding drive functional dimer states. [PDF]
Lima DCA +4 more
europepmc +1 more source
Regulation of protein kinases; controlling activity through activation segment conformation.
B. Nolen, Susan S. Taylor, G. Ghosh
semanticscholar +1 more source
The role of lipid metabolism in neuronal senescence
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Cryo-EM maps of human DNA polymerase ε should be reevaluated in light of its unexpected behavior in vitro. [PDF]
Roske JJ, Yeeles JTP.
europepmc +1 more source
Structure of a B-DNA dodecamer: conformation and dynamics.
H. Drew +6 more
semanticscholar +1 more source
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc +8 more
wiley +1 more source
Structural pharmacology of Chinese medicine: technological breakthroughs in decoding multi-target synergy and precision mechanisms. [PDF]
Wang C +5 more
europepmc +1 more source

