Results 221 to 230 of about 1,012,378 (302)

Visualising the membrane insertion mechanism of the bio-insecticide Vip3Aa by cryo-ET

Muench S, Hirst I, Lázaro-Berenguer M, Cutts A, Martínez PH, Scarff C, Berry C, Ferré J.   +7 more
europepmc   +1 more source

Conformational dynamics in insulin receptor kinase reveal a type III allosteric pocket. [PDF]

Protein Sci
Verma J, Vashisth H.
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Assessing conformation validity and rationality of deep learning-generated 3D molecules. [PDF]

Nat Commun
Fan F, Xi B, Meng X, Wang H, Zhang B, Xu Q, Feng W, Gao W, Wang X, Wang Y, Zhang H, Zhou F, Liu Z, Zhou W, Huang B.   +14 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Estimation of Double-Serine Phosphorylation's Effects on the Intrinsically Disordered Region Structure in Y14 (RBM8A) Protein via Molecular Dynamics Simulation. [PDF]

Cells
Nakamura Y, Horie T, Sakamoto T, Yoshizaki H, Okajima H, Ishigaki Y.   +5 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Conformal Tensor Invariants [PDF]

Proceedings of the National Academy of Sciences, 1934
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Ligand-specific conformational dynamics and interaction landscapes of hnRNPA2B1 reveal a structural basis for its functional regulation. [PDF]

Curr Res Struct Biol
Zhou Z, Li Y, Yang P, Zhu R, Li J, Wu B, Xu M, Yang N, Dai S.   +8 more
europepmc   +1 more source