Results 261 to 270 of about 663,489 (316)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Structural basis for allosteric regulation of mycobacterial guanosine 5´-monophosphate reductase by ATP and GTP. [PDF]

Nat Commun
Doležal M, Knejzlík Z, Kouba T, Filimoněnko A, Šváchová H, Dedola M, Klíma M, Pichová I.   +7 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Dissecting mechanisms of ligand binding and conformational changes in the glutamine-binding protein. [PDF]

Elife
Han Z, Panhans S, Brameyer S, Bilgen E, Ram M, Herr A, Narducci A, Isselstein M, Harris PD, Brix O, Con P, Jung K, Lamb DC, Lerner E, Griffith D, Weikl TR, Zijlstra N, Cordes T.   +17 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Carcass Characteristics and Meat Quality of Two Serbian Indigenous Chicken Breeds: Comparative Assessment of Banat Naked Neck and Svrljig Hen. [PDF]

Foods
Škrbić Z, Petričević V, Rakonjac S, Dosković V, Petričević M, Tolimir N, Lukić M.   +6 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Structural basis of transcription-coupled RNA damage by incorporation of oxidized ribonucleotides. [PDF]

Proc Natl Acad Sci U S A
Hou P, Lee C, Chong J, Oh J, Wang D.
europepmc   +1 more source

Stereoselective synthesis of 1'-α-cyano carbocyclic pyrimidine nucleoside analogs <i>via</i> a chelation-controlled 1'-α-hydroxymethylation strategy.

Org Biomol Chem
Biteau NG, Kasthuri M, Patel D, De R, Schinazi RF, Amblard F.   +5 more
europepmc   +1 more source

Structural basis for the differential recognition of integrin αvβ3 by rhodostomin and trimucrin. [PDF]

Commun Biol
Wang YT, Chang YT, Huang CH, Liau CT, Chen CY, Chuang WJ.   +5 more
europepmc   +1 more source