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Conformational disease

The Lancet, 1997
Several diverse disorders, including the prevalent dementias and encephalopathies, are now believed to arise from the same general disease mechanism. In each, there is abnormal unfolding and then aggregation of an underlying protein. The gradual accumulation of these aggregates and the acceleration of their formation by stress explain the ...
R W, Carrell, D A, Lomas
openaire   +2 more sources

Conformational Model

2008
The failure to identify changes in the crystal structure of the T-cell antigen receptor (TCR) alpha/beta ectodomains beyond the ligand-binding complementarity-determining region loops is most probably responsible for conformational changes having been relegated to a second plane as a mechanism of signal transduction.
Ruth M, Risueño   +2 more
openaire   +2 more sources

Conformational spectra — probing protein conformational changes

Biophysical Chemistry, 1999
Stafford [Biophys. J. 17 (1996) MP452] has shown that it is possible, using the analytical ultracentrifuge in sedimentation velocity mode, to calculate the molecular weights of proteins with a precision of approximately 5%, by fitting Gaussian distributions to g(s*) profiles so long as partial specific volume and the radial position of the meniscus are
N, Errington, O, Byron, A J, Rowe
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Do the number of robots and the participant’s gender influence conformity effect from multiple robots?

Adv. Robotics, 2019
The conformity effect is a critical social phenomenon through which one individual or a particular group influences the thoughts, feelings, or behaviors of another person or group.
M. Shiomi, N. Hagita
semanticscholar   +1 more source

Conformational toxicity and sporadic conformational diseases

Toxicology, 2000
Spontaneous, so-called 'conformational' diseases, specially of the neurodegenerative type like Alzheimer's, are linked to certain protein types which have the normal amino-acid sequence but are misfolded and accumulate due to resistance to proteolysis.
C, Reiss   +4 more
openaire   +2 more sources

The effects of facades of conformity on employee voice and job satisfaction

Management Decision, 2019
Purpose Employee voice can improve organizational and individual performance. The purpose of this paper is to consider individuals’ evaluations of various features of their work situations.
Hsin-Hui Chou, S. Fang, Tsung-Kai Yeh
semanticscholar   +1 more source

CONFORMAL TACHYONS

International Journal of Modern Physics A, 2000
We study tachyons conformally coupled to the background geometry of a Milne universe. The causality of superluminal signal transfer is scrutinized in this context. The cosmic time of the comoving frame determines a distinguished time order for events connected by superluminal signals.
openaire   +2 more sources

[Conformational diseases].

Ugeskrift for laeger, 2003
Conformational diseases are diseases where cellular functions are compromised because of misfolded proteins. The conceptional framework of conformational diseases is found in the cellular protein quality control systems which in the normal and young cell eliminate misfolded proteins.
Gregersen, N., Bross, P., Bolund, L.A.
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A Theory of Conformity

Journal of Political Economy, 1994
Douglas Bernheim
semanticscholar   +1 more source

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