Results 81 to 90 of about 2,057 (197)
Advanced Science, EarlyView.Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai +9 more
wiley +1 more source
Advanced Science, EarlyView.Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu +11 more
wiley +1 more source
Peningkatan Kualitas Permukiman Dengan Pendekatan Disain Pada Bantaran Sungai di Kelurahan Kebonsari
Emara: Indonesian Journal of Architecture, 2017 Housing and settlement are basic human needs and welfare in the merits of life. Other than serves as a residence, house has a strategic function in its role as the center of family education, cultural conformity and improving the future generations ...
Oktavi Elok Hapsari, Kusnul Prianto
doaj
A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers
Advanced Science, EarlyView.Phase separation and aging of intrinsically disordered proteins are placed in a unifying framework. A thermodynamically consistent time‐dependent version of associating‐polymer theory shows how the processes are intricately coupled. Assuming aging to occur through interacting sites resulting from reversible conformational transitions, the model ...
Jasper J. Michels +2 more
wiley +1 more source
Current Challenges of Transcription Compartmentalization Research
Advanced Science, EarlyView.Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley +1 more source
Advanced Science, EarlyView.This review focuses on green synthesis routes for lithium sulfide (Li2S)—a key material for lithium–sulfur batteries and sulfide solid electrolytes, whose traditional carbothermal reduction remains energy‐intensive and unsustainable. Specifically examined routes include low‐temperature solid‐state reactions, magnesiothermal reduction, and solution ...
Aiping Peng +11 more
wiley +1 more source
Advancing Energy Efficiency in Smart Windows via Dual‐Responsive Electro‐Thermochromism
Advanced Science, EarlyView.A durable and stable quasi‐solid‐state electro‐thermal dual‐responsive photothermal regulation device has been employed in advanced energy‐efficient smart windows. The devised device not only incorporates a thermochromic hydrogel characterized by high ionic conductivity, high optical transmittance, and a low LCST, but also comprises an electrochromic ...
Tongyu Chen +10 more
wiley +1 more source
Bio‐Based Polyurethanes for Sustainable and Multifunctional Applications
Advanced Science, EarlyView.Bio‐based polyurethanes prepared from vegetable oils, lignin, and polysaccharides have attracted increasing interest as alternatives to fossil‐derived polyurethanes. This review summarizes recent progress in their chemistry, structural engineering, and advanced applications, highlighting the roles of feedstocks, chain‐segment design, dynamic covalent ...
Xin Li +6 more
wiley +1 more source
Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy
Advanced Science, EarlyView.This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao +5 more
wiley +1 more source
ZnO Nanowires for Ultraviolet Detection: Recent Developments, Challenges, and Future Outlook
Advanced Electronic Materials, EarlyView.This work provides a comprehensive review of Zinc Oxide (ZnO) nanowires for high‐performance ultraviolet (UV) photodetection. By analyzing unique device physics and various detector architectures, it unveils strategies to overcome current performance limitations regarding speed and sensitivity.
Ala K. Jehad +4 more
wiley +1 more source