Results 111 to 120 of about 353,176 (298)

Methodological Frontiers in Environmental Epidemiology [PDF]

, 2011
Environmental epidemiology comprises the epidemiologic study of those environmental factors that are outside the immediate control of the individual.
Rothman, K J
core   +1 more source

Urea Level and Depression in Patients with Chronic Kidney Disease

Toxins
Depression is common in patients with chronic kidney disease (CKD). Experimental studies suggest the role of urea toxicity in depression. We assessed both the incidence of antidepressant prescriptions and depressive symptoms (measured by CESD (Center for
Hélène Levassort, Julie Boucquemont, Oriane Lambert, Sophie Liabeuf, Solene M. Laville, Laurent Teillet, Abdel-Hay Tabcheh, Luc Frimat, Christian Combe, Denis Fouque, Maurice Laville, Christian Jacquelinet, Catherine Helmer, Natalia Alencar de Pinho, Marion Pépin, Ziad A. Massy, on behalf of CKD-REIN Study Collaborators   +16 more
doaj   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Effects of SO2 on respiratory system of adult Miyakejima resident 2 years after returning to the island.

, 2009
BACKGROUND: Mt. Oyama in Miyakejima Island erupted in June, 2000. All Miyake villagers were forced to evacuate from the island in September, 2000, due to continuous eruptions and emissions of unsafe amounts of volcanic gas, mainly SO2.
Ai Ishigami, Akihiro Morikawa, Clinical Pulmonary Functions Committee of The Japanese Respiratory Society, Committee for Air Pollution in Kinki Area, Epidemiology Standardization Project, Fujii T, Hiroshi Nakashima, Iwao Uchiyama, Kazuyuki Omae, Kikuchi Y, Kouichi Maruyama, Makiko Nakano, Mannino DM, Mitsuru Adachi, Satoko Iwasawa, Shigeru Tanaka, Shoji Kudo, Takamoto Uemura, Takehiro Michikawa, Tazuru Tsuboi, Toru Takebayashi, Yuji Nishiwaki, Yuriko Kikuchi   +22 more
core   +1 more source

Drug-induced acute myocardial infarction: identifying 'prime suspects' from electronic healthcare records-based surveillance system.

PLoS ONE, 2013
BackgroundDrug-related adverse events remain an important cause of morbidity and mortality and impose huge burden on healthcare costs. Routinely collected electronic healthcare data give a good snapshot of how drugs are being used in 'real-world ...
Preciosa M Coloma, Martijn J Schuemie, Gianluca Trifirò, Laura Furlong, Erik van Mulligen, Anna Bauer-Mehren, Paul Avillach, Jan Kors, Ferran Sanz, Jordi Mestres, José Luis Oliveira, Scott Boyer, Ernst Ahlberg Helgee, Mariam Molokhia, Justin Matthews, David Prieto-Merino, Rosa Gini, Ron Herings, Giampiero Mazzaglia, Gino Picelli, Lorenza Scotti, Lars Pedersen, Johan van der Lei, Miriam Sturkenboom, EU-ADR consortium   +24 more
doaj   +1 more source

The Association between Vitamin D 25(OH)D Level and Albuminuria in Type 2 Diabetes Mellitus

Jurnal Penyakit Dalam Indonesia, 2017
Introduction. Vitamin D 25(OH)D deficiency was reported as a possible risk factor for the development of diabetic nephropathy in several epidemiologic studies.
Tities Anggraeni Indra, Aida Lydia, Dyah Purnamasari, Siti Setiati   +3 more
doaj   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Accuracy of the HumaSensplus point-of-care uric acid meter using capillary blood obtained by fingertip puncture

Arthritis Research & Therapy, 2018
Background The uric acid (UA) level in patients with gout is a key factor in disease management and is typically measured in the laboratory using plasma samples obtained after venous puncture.
Stéphanie Fabre, Pierre Clerson, Jean-Marie Launay, Jean-François Gautier, Tiphaine Vidal-Trecan, Jean-Pierre Riveline, Adam Platt, Anna Abrahamsson, Jeffrey N. Miner, Glen Hughes, Pascal Richette, Thomas Bardin   +11 more
doaj   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Student evaluations of teaching effectiveness: the interpretation of observational data and the principle of faute de mieux [PDF]

, 1995
Student opinion surveys are important but widely misunderstood tools for evaluating teaching effectiveness. In this brief review, an analogy is drawn between the use and interpretation of observational data for public health and biomedical research and ...
Gerstman, B. Burt
core   +1 more source