Results 141 to 150 of about 97,061 (270)

Metformin enhances external urethral sphincter integrity and restores continence via AMPK activation in a rat model of stress urinary incontinence

Animal Models and Experimental Medicine, EarlyView.
The pathogenesis of stress urinary incontinence (SUI) is intimately associated with injury to the external urethral sphincter (EUS). In this study, we established an SUI model induced by double vaginal distension and demonstrated that metformin treatment activated the AMPK signaling in the EUS tissue.
Yuting Xu, Xuhong Li, Alvaro Munoz, Li Jiang, Lihua Huang, Yanhua Zhou, Liping Zhu, Youbo Yang   +7 more
wiley   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Multi‐omics data mining combined with experimental validation reveals ferroptosis‐ and autophagy‐associated hub genes as diagnostic candidates and immune modulators in atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
Using the GSE225650 dataset, we performed differential expression gene (DEG) screening, Weighted Gene Coexpression Network Analysis (WGCNA), and immune infiltration profiling on atherosclerosis (AS) samples, yielding 104 shared candidate genes. Subsequently, these 104 candidate genes were intersected with ferroptosis‑ and autophagy‑related gene sets ...
Xinou Zheng, Jinling Zheng, Xuezhuang Li, Hua Chen, Li Zhang, Yuqiong Zhao, Yahao Ling   +6 more
wiley   +1 more source

Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers

Annals of Neurology, EarlyView.
Objective Multimorbidity, the coexistence of 2 or more chronic conditions, has been linked to cognitive aging and Alzheimer's disease (AD) and AD‐related dementias, yet the mechanisms remain unclear. We aimed to examine the associations of multimorbidity with cognition and biomarkers across multiple mechanistic pathways.
Xiaqing Jiang, Sid E. O'Bryant, Robert A. Rissman, Leigh A. Johnson, Meredith N. Braskie, Kristine Yaffe, the HABS‐HD Study Team, Sid E. O'Bryant, Kristine Yaffe, Arthur Toga, Robert Rissman, Leigh Johnson, Meredith Braskie, Kevin King, James R. Hall, Melissa Petersen, Raymond Palmer, Robert Barber, Yonggang Shi, Fan Zhang, Rajesh Nandy, Roderick McColl, David Mason, Bradley Christian, Nicole Phillips, Stephanie Large, Joe Lee, Badri Vardarajan, Monica Rivera Mindt, Amrita Cheema, Lisa Barnes, Mark Mapstone, Annie Cohen, Amy Kind, Ozioma Okonkwo, Raul Vintimilla, Zhengyang Zhou, Michael Donohue, Rema Raman, Matthew Borzage, Michelle Mielke, Beau Ances, Ganesh Babulal, Jorge Llibre‐Guerra, Carl Hill, Rocky Vig   +45 more
wiley   +1 more source

Pre‐Diagnostic Plasma Carotenoids, Tocopherols and Retinol Levels, and Risk of Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Our goal was to examine whether pre‐diagnostic plasma carotenoids and tocopherols are associated with amyotrophic lateral sclerosis (ALS). Methods A nested case–control study within 4 United States cohorts, where 154 participants with pre‐diagnostic blood‐draw, were diagnosed during follow‐up with amyotrophic lateral sclerosis (ALS). Controls
Éilis J. O'Reilly, Kjetil Bjornevik, Jeremy D. Furtado, Alpa V. Patel, Ying Wang, Laurence N. Kolonel, Loïc Le Marchand, Alberto Ascherio   +7 more
wiley   +1 more source

Chronic Kidney Disease in Dogs in UK Veterinary Practices: Prevalence, Risk Factors, and Survival [PDF]

, 2013
Bartges, Bartges, Bartges, Bartlett, Bartlett, Bronden, Brown, Chandler, Chen, DiBartola, DiBartola, Doherr, Dohoo, Drobatz, Egenvall, Elliott, Elliott, Gardner, Glickman, Grauer, Gregory, Heinze, Hosmer, Jones, Kirkwood, Lees, Lees, Liberg, Ling, Lund, Macdougall, Marinelli, McAloose, McV Messam, Müller-Peddinghaus, Nelson, Nicolle, Oliver, Polzin, Polzin, Schiffrin, Sosnar, Su, Tenhündfeld, The VeNom Coding Group, Thomas, Upjohn, Vaden, Vleck   +48 more
core   +2 more sources

Potential Health Impacts of Jet Fuel Exposure on the Hematologic and Cardiovascular Systems. [PDF]

J Occup Environ Med
Ross AM, Vidal J, Freedman AN, Kolanowski A, Miller SL, Goodman SJ, Sprowles JLN, Lindahl AJ, Snow SJ, Eftim SE, Haver CE, Vincent-Hall TD.   +11 more
europepmc   +1 more source

Rethinking Maternal Obesity Research in a Changing Clinical Landscape. [PDF]

Paediatr Perinat Epidemiol
Hutcheon JA, Bodnar LM.
europepmc   +1 more source

Rethinking brachycephaly: Anatomical implications and health considerations in lagomorphs

The Anatomical Record, EarlyView.
Abstract Brachycephaly in domestic rabbits is increasingly perceived by welfare organizations as associated with significant health complications, particularly oral pathologies. Despite this perception, comparative anatomical research into rabbit brachycephaly is limited compared to that of dogs and cats, compelling an in‐depth examination of its ...
Helaina Cressy, Alice Nishigaki, Matthew C. Gage, Renato L. Previdelli   +3 more
wiley   +1 more source

<i>Porphyromonas gingivalis</i>-Associated Modulation of β-Catenin Signaling in Oral Squamous Cell Carcinoma: Molecular Perspectives from Periodontal Dysbiosis. [PDF]

Molecules
Hashim NT, Babiker R, Mohammed R, Elsheikh M, Padmanabhan V, Islam MS, Gesm Elseed M, Chaitanya NCSK, Siriwardena BSMS, Rahman MM, Gismalla BG.   +10 more
europepmc   +1 more source