Results 41 to 50 of about 21,079 (337)

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

FEBS Letters, EarlyView.
Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta, Agnieszka Katarzyna Maciola, Tania Baccega, Giulia Pasqual   +3 more
wiley   +1 more source

Factors affecting the polychlorinated biphenyl signatures in serum of adults living in a highly polluted area in eastern Slovakia

Frontiers in Public Health
IntroductionOver the years eastern Slovakia has been subject to consistent monitoring of high levels of polychlorinated biphenyls (PCBs) in both the environment and human populations attributed to the former production of PCBs at the Chemko Strážske ...
Henrieta Hlisníková, Branislav Kolena, Tomáš Trnovec, Denisa Richterová Bagratuni, Henrieta Patayová, Kamil Čonka, Beata Drobná, Katarína Rausová, Juraj Tihányi, Soňa Wimmerová, Ida Petrovičová, Miroslava Nagyová, Ľubica Palkovičová Murínová   +12 more
doaj   +1 more source

Addition to the known diversity of Chinese freshwater mussels: integrative description of a new species of Postolata Dai et al., 2023 (Bivalvia, Unionidae, Gonideinae) [PDF]

Zoosystematics and Evolution
In this study, we present a new species of freshwater mussel in the genus Postolata Dai et al., 2023, from Guangxi Province, China, by integrating morphological, anatomical, and molecular data. Postolata longjiangensis Liu & Wu, sp. nov.
Lili Liu, Liping Zhang, Kaiyu Hou, Liyang Ning, Ruiwen Wu   +4 more
doaj   +3 more sources

The effect of polychlorinated biphenyls on the song of two passerine species. [PDF]

PLoS ONE, 2013
Polychlorinated biphenyls (PCBs) are synthetic chemical pollutants with demonstrated detrimental toxic and developmental effects on humans and wildlife.
Sara DeLeon, Rayko Halitschke, Ralph S Hames, André Kessler, Timothy J DeVoogd, André A Dhondt   +5 more
doaj   +1 more source

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Serum PCB levels and congener profiles among teachers in PCB-containing schools: a pilot study

Environmental Health, 2011
Background PCB contamination in the built environment may result from the release of PCBs from building materials. The significance of this contamination as a pathway of human exposure is not well-characterized, however.
Altshul Larisa, Meeker John D, Herrick Robert F   +2 more
doaj   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Nationwide PCB congener pattern analysis in freshwater fish samples in France

Knowledge and Management of Aquatic Ecosystems, 2013
The 2006 european directive on polychlorodibenzodioxins and related compounds in foodstuffs prompted in France a nationwide monitoring study of freshwater fish contamination by these compounds.
Babut M., Mathieu A., Pradelle S., Marchand P., Le Bizec B., Perceval O.   +5 more
doaj   +1 more source

Repurposing Synthetic Congeners of a Natural Product Aurone Unveils a Lead Antitumor Agent Inhibiting Folded P-Loop Conformation of MET Receptor Tyrosine Kinase

Pharmaceuticals, 2023
A library of 24 congeners of the natural product sulfuretin were evaluated against nine panels representing nine cancer diseases. While sulfuretin elicited very weak activities at 10 µM concentration, congener 1t was identified as a potential compound ...
Ahmed H. E. Hassan, Cai Yi Wang, Cheol Jung Lee, Hye Rim Jeon, Yeonwoo Choi, Suyeon Moon, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Kazem Mahmoud, Selwan M. El-Sayed, Sang Kook Lee, Yong Sup Lee   +12 more
doaj   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source