Results 11 to 20 of about 869,874 (249)

Lactococcus lactis provides an efficient platform for production of disulfide-rich recombinant proteins from Plasmodium falciparum

Microbial Cell Factories, 2018
Background The production of recombinant proteins with proper conformation, appropriate post-translational modifications in an easily scalable and cost-effective system is challenging.
Susheel K. Singh, Régis Wendpayangde Tiendrebeogo, Bishwanath Kumar Chourasia, Ikhlaq Hussain Kana, Subhash Singh, Michael Theisen   +5 more
doaj   +1 more source

Textbook outcome for the Norwood operation—an informative quality metric in congenital heart surgeryCentral MessagePerspective

JTCVS Open, 2023
Objectives: To develop a more holistic measure of center performance than operative mortality, we created a composite “textbook outcome” for the Norwood operation using several postoperative end points. We hypothesized that achieving the textbook outcome
Neel K. Prabhu, MD, Joseph R. Nellis, MD, MBA, Mary Moya-Mendez, MS, Anna Hoover, BS, Cathlyn Medina, BS, James M. Meza, MD, MSc, Veerajalandhar Allareddy, MBBS, MBA, Nicholas D. Andersen, MD, Joseph W. Turek, MD, PhD, MBA   +8 more
doaj   +1 more source

Protein-losing enteropathy in Fontan circulation: Pathophysiology, outcome and treatment options of a complex condition

International Journal of Cardiology Congenital Heart Disease, 2022
Protein-losing enteropathy (PLE) represents a rare but severe and potentially life-threatening complication following Fontan operation in patients with a functional single ventricle.
Rosaria Barracano, Assunta Merola, Flavia Fusco, Giancarlo Scognamiglio, Berardo Sarubbi   +4 more
doaj   +1 more source

A “long-standing” malpositioned pacing lead. Long-term follow-up after extraction

Monaldi Archives for Chest Disease, 2018
Transvenous pacemaker (PM) catheters can be unintentionally placed in the left ventricle (LV) during the implantation procedure. An 8-year-old girl was discovered with a malpositioned pm wire, seven years after the implant.
Berardo Sarubbi, Giancarlo Scognamiglio, Flavia Fusco, Enrico Melillo, Michele D'Alto, Maria Giovanna Russo   +5 more
doaj   +1 more source

Imaging of ventricular septal defect: Native and post-repair

International Journal of Cardiology Congenital Heart Disease, 2022
Cardiac imaging using a combination of multiple modalities has become an essential tool in the management of adults with congenital heart disease with the potential to improve the outcome.
Flavia Fusco, Nunzia Borrelli, Michela Palma, Berardo Sarubbi, Giancarlo Scognamiglio   +4 more
doaj   +1 more source

Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects

Cell Death and Disease, 2021
Impaired autophagy and excessive apoptosis disrupt cellular homeostasis and contribute to neural tube defects (NTDs), which are a group of fatal and disabling birth defects caused by the failure of neural tube closure during early embryonic development ...
Wanqi Huang, Tianchu Huang, Yusi Liu, Jialin Fu, Xiaowei Wei, Dan Liu, Wei Ma, Hui Gu, Zhengwei Yuan   +8 more
doaj   +1 more source

Understanding the current status of patients with pulmonary hypertension during COVID-19 outbreak: a small-scale national survey from China

Pulmonary Circulation, 2020
Pulmonary hypertension is a chronic disease developing progressively with high mortality. Pulmonary hypertension patients need persistent medical care; however, limited reports focused on them when there was an outbreak of coronavirus disease 2019 in ...
Hongmei Zhou, Gangcheng Zhang, Xiaoxian Deng, Bowen Jin, Qiu Qiu, Menghuan Yan, Xi Wang, Xuan Zheng   +7 more
doaj   +1 more source

Feasibility and effectiveness of telemedicine for adult patients with congenital heart disease: A one-year single-center experience-based studySummary table

International Journal of Cardiology Congenital Heart Disease
Introduction: The number of adults with congenital heart disease has significantly increased in recent years. While telemedicine has emerged as a promising approach to improve care delivery and patient outcomes, its use for adults with congenital ...
Nunzia Borrelli, Nicola Grimaldi, Flavia Fusco, Antonio Orlando, Michela Palma, Maria Cristina Boccia, Sabrina Bassolino, Anna Iervolino, Berardo Sarubbi   +8 more
doaj   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Progressive familial intrahepatic cholestasis type 4: a case report

Journal of Medical Case Reports
Background Progressive familial intrahepatic cholestasis is an autosomal recessive genetic disorder that manifests primarily with jaundice and pruritus and can progresses from persistent cholestasis to cirrhosis and late childhood liver failure ...
Mohamed Abdelmalak Abokandil, Saber Waheeb, Wessam Zaghloul, Manal Abdelgawad, Mona Abdelhady, Mohamed Mansy, Mostafa Kotb   +6 more
doaj   +1 more source