Results 31 to 40 of about 760 (168)

Comparison of coagulation parameters associated with fibrinogen concentrate and cryoprecipitate for treatment of bleeding in patients undergoing cytoreductive surgery for pseudomyxoma peritonei: Subanalysis from a randomized, controlled phase 2 study

Health Science Reports, Volume 6, Issue 9, September 2023., 2023
Abstract Background and Aims The FORMA‐05 study compared the efficacy and safety of human fibrinogen concentrate (HFC) versus cryoprecipitate for hemostasis in bleeding patients undergoing cytoreductive surgery for pseudomyxoma peritonei (PMP). This subanalysis explores coagulation parameters in the FORMA‐05 patients, with a focus on the seven patients
Ashok Roy, Nigel Sargant, John Bell, Sophia Stanford, Cristina Solomon, Irina Kruzhkova, Sigurd Knaub, Faheez Mohamed   +7 more
wiley   +1 more source

Targeted mutation of zebrafish fga models human congenital afibrinogenemia. [PDF]

Blood, 2014
Mutations in the human fibrinogen genes can lead to the absence of circulating fibrinogen and cause congenital afibrinogenemia. This rare bleeding disorder is associated with a variable phenotype, which may be influenced by environment and genotype. Here,
Fish RJ, Di Sanza C, Neerman-Arbez M.
europepmc   +2 more sources

Management of rare inherited bleeding disorders: Proposals of the French Reference Centre on Haemophilia and Rare Coagulation Disorders

European Journal of Haematology, Volume 110, Issue 6, Page 584-601, June 2023., 2023
Abstract Introduction The rare coagulation disorders may present significant difficulties in diagnosis and management. In addition, considerable inter‐individual variation in bleeding phenotype is observed amongst affected individuals, making the bleeding risk difficult to assess in affected individuals.
Marc Trossaert, Valerie Chamouard, Christine Biron‐Andreani, Alessandro Casini, Philippe De Mazancourt, Emmanuelle De Raucourt, Nicolas Drillaud, Birgit Frotscher, Benoit Guillet, Aurelien Lebreton, Valerie Roussel‐Robert, Lucia Rugeri, Yesim Dargaud   +12 more
wiley   +1 more source

Diagnostic utility of bleeding assessment tools in congenital fibrinogen deficiencies

Haemophilia, Volume 29, Issue 3, Page 827-835, May 2023., 2023
Abstract Background The assessment of clinical history is crucial before referring a patient for further laboratory testing. Bleeding assessment tools (BAT) are developed to standardize clinical evaluation. A small number of patients with congenital fibrinogen deficiencies (CFDs) have been evaluated with these tools without definitive results.
Samin Mohsenian, Omid Seidizadeh, Roberta Palla, Mohammad Jazebi, Azita Azarkeivan, Somayeh Moazezi, Mohammad Reza Baghaipour, Marzia Menegatti, Flora Peyvandi   +8 more
wiley   +1 more source

Congenital fibrinogen deficiency in Hemophilia Center Medical City/Baghdad

Iraqi Journal of Hematology, 2021
CONTEXT: Congenital fibrinogen deficiency is a rare inherited coagulation disorder with an estimated prevalence of 1:1,000,000 which is characterized by bleeding that varies from mild to severe and by an extremely low level or complete absence of plasma ...
Afrah A Salih, Murtadha H Ali, Mohammed J Alwan   +2 more
doaj   +1 more source

Coagulation Dysfunction in Patients with Liver Cirrhosis and Splenomegaly and Its Countermeasures: A Retrospective Study of 1522 Patients

Disease Markers, Volume 2023, Issue 1, 2023., 2023
Objective. Patients with cirrhosis and splenomegaly often have coagulation dysfunction which affects treatment and prognosis. This study explores the status, grading, and treatment strategies of coagulation dysfunction in patients with liver cirrhosis and splenomegaly. Methods.
Yunfu Lv, Ning Liu, Yejuan Li, Jincai Wu, Jinfang Zheng, Xinqiu Li, Min Zeng, Zhengwen Liu   +7 more
wiley   +1 more source

Congenital afibrinogenemia in a 4-year-old girl complicated with acute lymphoblastic leukemia

The Turkish Journal of Pediatrics, 2020
Background. Congenital fibrinogen deficiency is one of the rare inherited coagulation disorders. Congenital fibrinogen deficiency complicated with a hematological malignancy can be life threatening. Case.
Alper Özcan, Bahadır Samur, Şefika Akyol, Necdet Arda Erdoğmuş, Türkan Patıroğlu, Musa Karakükçü, Ekrem Ünal   +6 more
doaj   +1 more source

Analysis of fibrinogen concentrate pharmacokinetics and dosing for bleeds and surgery in adults, adolescents, and children with congenital afibrinogenaemia and hypofibrinogenaemia

Haemophilia, Volume 28, Issue 6, Page 1022-1032, November 2022., 2022
Abstract Introduction Congenital afibrinogenaemia and hypofibrinogenaemia are rare coagulation disorders where clotting is impaired due to a lack of fibrinogen. Consequent bleeding episodes (BEs) are treated using human fibrinogen concentrate (HFC). Aim This post‐hoc analysis compared HFC pharmacokinetics (PK) and dosing between patient age groups and ...
Claudia Djambas Khayat, Sunil D. Lohade, Omid R. Zekavat, Irina Kruzhkova, Cristina Solomon, Sigurd Knaub, Flora Peyvandi   +6 more
wiley   +1 more source

Nonketotic hyperosmolar coma associated with splenic rupture in congenital afibrinogenemia [PDF]

, 2004
Nonketotic hyperosmolar coma is uncommon in children. Splenic rupture in congenital afibrinogenemia is also a rare event. The authors described a 5-year-old girl with congenital afibrinogenemia who presented with nonketotic hyperosmolar coma associated ...
Patiroglu, Türkan, KESKIN, M, GOZUKUCUK, Ali, AKCAKUS, Mustafa, KOKLU, Esad   +4 more
core   +1 more source

Plasma viscosity pattern and erythrocyte aggregation in two patients with congenital afibrinogenemia [PDF]

, 2020
In this case report, we examine the behavior of plasma viscosity, explored at high and low shear rates, and erythrocyte aggregation in two patients with congenital afibrinogenemia, a clinical disorder firstly described in 1920 and that has an estimated ...
Gregorio Caimi, Caimi, Gregorio, Mariasanta Napolitano, Simona Raso, Lo Presti, Rosalia, Raso, Simona, Napolitano, Mariasanta, Rosalia Lo Presti, Siragusa, Sergio, Sergio Siragusa   +9 more
core   +1 more source