Results 31 to 40 of about 1,250 (185)
Disease Markers, Volume 2023, Issue 1, 2023., 2023 Objective. Patients with cirrhosis and splenomegaly often have coagulation dysfunction which affects treatment and prognosis. This study explores the status, grading, and treatment strategies of coagulation dysfunction in patients with liver cirrhosis and splenomegaly. Methods.
Yunfu Lv +7 more
wiley +1 more source
Congenital fibrinogen deficiency in Hemophilia Center Medical City/Baghdad
Iraqi Journal of Hematology, 2021 CONTEXT: Congenital fibrinogen deficiency is a rare inherited coagulation disorder with an estimated prevalence of 1:1,000,000 which is characterized by bleeding that varies from mild to severe and by an extremely low level or complete absence of plasma ...
Afrah A Salih +2 more
doaj +1 more source
Haemophilia, Volume 28, Issue 6, Page 1022-1032, November 2022., 2022 Abstract Introduction Congenital afibrinogenaemia and hypofibrinogenaemia are rare coagulation disorders where clotting is impaired due to a lack of fibrinogen. Consequent bleeding episodes (BEs) are treated using human fibrinogen concentrate (HFC). Aim This post‐hoc analysis compared HFC pharmacokinetics (PK) and dosing between patient age groups and ...
Claudia Djambas Khayat +6 more
wiley +1 more source
Congenital afibrinogenemia in a 4-year-old girl complicated with acute lymphoblastic leukemia
The Turkish Journal of Pediatrics, 2020 Background. Congenital fibrinogen deficiency is one of the rare inherited coagulation disorders. Congenital fibrinogen deficiency complicated with a hematological malignancy can be life threatening. Case.
Alper Özcan +6 more
doaj +1 more source
Misdiagnosis of a patient with congenital dysfibrinogenemia: A case report and literature review
Journal of Clinical Laboratory Analysis, Volume 36, Issue 9, September 2022., 2022 Use PT‐derived assay when fibrinogen level is reduced and thrombin time is prolonged. Abstract Background We reported a patient with congenital dysfibrinogenemia who was misdiagnosed and reviewed relevant literature, in order to discuss the methods to reduce misdiagnosis.
Xinyan Chen +3 more
wiley +1 more source
Clinical, biological, and genetic features in an afibrinogenemia patient series in Algeria
Haemophilia, Volume 28, Issue 5, Page 822-831, September 2022., 2022 Abstract Introduction The incidence of afibrinogenemia had not been previously reported in Algeria. Afibrinogenemia patients are prone to both haemorrhagic and thrombotic complications. Predictive markers of thrombosis in afibrinogenemia patients are not existent.
Soraya Hadjali‐Saichi +8 more
wiley +1 more source
Thrombosis Journal, 2018 Background Patients with congenital afibrinogenemia suffer from spontaneous recurrent severe bleeding. While fibrinogen concentrates are known to effectively treat bleeding episodes, thrombotic complications often occur upon replacement therapy ...
S. Le Quellec +6 more
doaj +1 more source
Pseudohomozygous dysfibrinogenemia [PDF]
, 2021 Hypodysfibrinogenemia (HD) is a heterogeneous disorder in which plasma fibrinogen antigen and function are both reduced but discordant. This report addresses the key clinical question of whether genetic analysis enables clinically useful ...
Doherty, Christopher +5 more
core +2 more sources
siRNA down-regulation of FGA mRNA in HepG2 cells demonstrated that heterozygous abnormality of the A alpha-chain gene does not affect the plasma fibrinogen level [PDF]
, 2013 Introduction: We encountered two afibrinogenemia patients with homozygous and compound heterozygous FGA mutation. Of interest, the patients' parents, who are heterozygous, had normal levels of plasma fibrinogen; thus, we hypothesized that liver FGA mRNA ...
Honda, Takayuki +5 more
core +4 more sources
A C-terminal amino acid substitution in the γ-chain caused by a novel heterozygous frameshift mutation (Fibrinogen Matsumoto VII) results in hypofibrinogenaemia [PDF]
, 2010 journal ...
Fujihara Noriko +6 more
core +2 more sources