Results 101 to 110 of about 330,544 (344)

Prevalence and Etiology of Heart Murmurs in 2-24-Months-Old Infants Kerman, Iran [PDF]

: Background & aim: Congenital heart disease is one of the most common malformations at birth that require timely recognition and treatment. The aim of this study was to determine the prevalence and etiology of detected heart murmurs and association ...
Bagheri M.M., M.D., Torabi-Nezhad M.H., M.D., Jamali Z., M.D., B,
core  

Prenatal diagnosis and prevalence of critical congenital heart defects: an international retrospective cohort study

BMJ Open, 2019
Objectives To assess international trends and patterns of prenatal diagnosis of critical congenital heart defects (CCHDs) and their relation to total and live birth CCHD prevalence and mortality.
M. Bakker, J. Bergman, S. Krikov, E. Amar, G. Cocchi, J. Cragan, H. D. de Walle, M. Gatt, B. Groisman, Shiliang Liu, W. Nembhard, A. Pierini, A. Rissmann, Shanthi Chidambarathanu, Antonin Sipek Jr, E. Szabová, G. Tagliabue, D. Tucker, P. Mastroiacovo, L. Botto   +19 more
semanticscholar   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Fetal Pain Perception: Legislative Assertions and Developmental Neuroscience

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Background Pain perception is a conscious experience, but neither pain nor consciousness is defined in the developing human fetus. Emergent consciousness may be regarded as a phenomenon that ultimately arises from an essential minimum of functional neuronal connectivity. Proposed U.S.
William D. Graf, Timothy M. Crombleholme, Leon G. Epstein, Dawn Gano, Phillip L. Pearl, Timothy V. Salomons, Mark S. Scher, Elise Turk, Klaus‐Peter Zimmer, Harvey B. Sarnat   +9 more
wiley   +1 more source

Common arterial trunk: pathomorphological changes of unoperated cardiac defect in adulthood

Patologìâ, 2018
Congenital heart defects in adulthood constitute the sufficient proportion of cardiac pathology. The common arterial trunk (CAT) is one of the сongenital cardiac defects that is described in the adult population.
V. I. Hryhoriichuk, Yu. I. Kuzyk, O. I. Boiko   +2 more
doaj   +1 more source

Identification of novel genes regulating the development of the palate

Developmental Dynamics, EarlyView.
Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley   +1 more source

Heterozygous Med13l mice recapitulate a developmental growth delay and craniofacial anomalies seen in MED13L syndrome

Developmental Dynamics, EarlyView.
Abstract Background Gene transcription is crucial for embryo and postnatal development and is regulated by the Mediator complex. Mediator is comprised of four submodules, including the kinase submodule (CKM). The CKM consists of MED13, MED12, CDK8, and CCNC.
Anna K. Leinheiser, Timothy T. Nguyen, Kayla M. Henry, Mariela Rosales, Eric Van Otterloo, Chad E. Grueter   +5 more
wiley   +1 more source

Frequency and pattern of adult congenital heart disease in a tertiary care cardiac hospital: reasons associated with delayed diagnosis

Journal of the Pakistan Medical Association
Objective: To determine the distribution pattern and possible reasons of delayed diagnosis of congenital heart disease in adult population. Method: The analytical, cross-sectional study was conducted at the Department of Paediatric Cardiology ...
Aliya Kemal Ahsan, Rumana Sangi, Abdul Sattar Shaikh, Mohammad Mohsin, Saba Mumtaz   +4 more
doaj   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source