Results 51 to 60 of about 257,105 (351)

Large‐Scale Bioprinting of Human Epiblast‐Like Models Featuring Disc‐Shaped Morphogenesis and Gastrulation Events

Advanced Science, EarlyView.
Large‐scale generation of disc‐shaped models mimicking human epiblast layer is achieved by bioprinting of human pluripotent stem cells using a well‐defined biomatrix. The bioactive component and physical confinement from laminin/alginate microgels, combined with the endogenous regulation of the WNT signaling pathway regulated disc‐like morphogenesis ...
Yixue Luo, Liheng Luo, Ling Wang, Shanshan Yang, Hongan Ren, Shaojun Liang, Xiaoyu Wang, Yijun Su, Leqian Yu, Xiaoyue Wang, Mingen Xu, Rui Yao   +11 more
wiley   +1 more source

Prevalence and Etiology of Heart Murmurs in 2-24-Months-Old Infants Kerman, Iran [PDF]

Journal of Kerman University of Medical Sciences, 2014
Background & aim: Congenital heart disease is one of the most common malformations at birth that require timely recognition and treatment. The aim of this study was to determine the prevalence and etiology of detected heart murmurs and association ...
M.M Bagheri, M.H Torabi-Nezhad, Z Jamali, M.R Baneshi   +3 more
doaj  

Maternal Homocysteine and Congenital Heart Defects

Journal of the American College of Cardiology, 2006
To the Editor: An estimated 80% of congenital heart defects result from an interaction between susceptibilities in parental and fetal genomes and environmental exposures including maternal lifestyle factors ([1][1]). We and others have recently reported that women who have congenital heart defect-
Weizhi Zhao, Charlotte A. Hobbs, S. Jill James, Stepan Melnyk, Sadia Malik, Mario A. Cleves   +5 more
openaire   +3 more sources

Large Language Model‐Based Chatbots in Higher Education

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
The use of large language models (LLMs) in higher education can facilitate personalized learning experiences, advance asynchronized learning, and support instructors, students, and researchers across diverse fields. The development of regulations and guidelines that address ethical and legal issues is essential to ensure safe and responsible adaptation
Defne Yigci, Merve Eryilmaz, Ail K. Yetisen, Savas Tasoglu, Aydogan Ozcan   +4 more
wiley   +1 more source

Ventricular Function in Congenital Heart Defects [PDF]

Frontiers in Pediatrics, 2016
In order to understand the physiology of the neonatal heart, one must have an understanding of both the fetal circulation and the cardiac function of the adult heart. Transitional changes occur in the neonatal period, where the function of one ventricle has important effects on the function of the contralateral ventricle (1).
openaire   +3 more sources

Phenotypic Characterization of Seven Pediatric Patients Diagnosed With KAT6B‐Related Disorders: Case Series and Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Genitopatellar syndrome (GPS) and Say‐Barber‐Biesecker‐Young‐Simpson Syndrome (SBBYSS) are clinically distinct neurodevelopmental disorders caused by monoallelic pathogenic variants in KAT6B. In some cases, GPS and SBBYSS features can overlap, determining an intermediate phenotype.
Vittorio Maglione, Antonio Pizzuti, Gioia Mastromoro, Eleonora Cresta, Paola Favata, Maria Cristina Digilio, Rossella Capolino, Maria Lisa Dentici, Lorenzo Sinibaldi, Antonio Novelli, Marco Tartaglia, Gianluca Terrin, Viviana Cardilli   +12 more
wiley   +1 more source

The detailed profile of congenital heart diseases in 254 children with Down syndrome in Saudi Arabia

The Cardiothoracic Surgeon
Background Down syndrome is the most common chromosomal abnormality in humans. It is associated with several congenital anomalies, including a spectrum of congenital heart diseases.
Naif Alkhushi
doaj   +1 more source

Postnatal Cardiac Autonomic Nervous Control in Pediatric Congenital Heart Disease

Journal of Cardiovascular Development and Disease, 2016
Congenital heart disease is the most common congenital defect. During childhood, survival is generally good but, in adulthood, late complications are not uncommon.
Ineke Nederend, Monique R. M. Jongbloed, Eco J. C. de Geus, Nico A. Blom, Arend D. J. ten Harkel   +4 more
doaj   +1 more source

Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16

Nature Genetics, 2013
We carried out a genome-wide association study (GWAS) of congenital heart disease (CHD). Our discovery cohort comprised 1,995 CHD cases and 5,159 controls and included affected individuals from each of the 3 major clinical CHD categories (with septal ...
H. Cordell, J. Bentham, A. Töpf, D. Zélénika, S. Heath, Chrysovalanto Mamasoula, C. Cosgrove, G. Blue, J. Granados-Riverón, Kerry Setchfield, Chris Thornborough, J. Breckpot, Rachel Soemedi, Ruairidh Martin, T. Rahman, D. Hall, K. Engelen, A. Moorman, A. Zwinderman, P. Barnett, T. Koopmann, M. Adriaens, A. Varró, A. George, C. D. Remedios, N. Bishopric, C. Bezzina, J. O’Sullivan, M. Gewillig, F. Bu'Lock, D. Winlaw, S. Bhattacharya, K. Devriendt, J. Brook, B. Mulder, S. Mital, A. Postma, G. Lathrop, M. Farrall, J. Goodship, B. Keavney, B. Keavney   +41 more
semanticscholar   +1 more source

Truncating Variants in RREB1 Cause a Novel RASopathy Syndrome of Congenital Heart Disease, Genitourinary Malformations, and Developmental Delay

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The interstitial 6p microdeletion syndrome is characterized by dysmorphic facies and structural heart, kidney, brain, and musculoskeletal differences. RREB1 haploinsufficiency and consequent abnormal RAS‐MAPK pathway signaling have been proposed as a driver of the disease phenotype; however, apart from a single case report, the phenotype of ...
Alanna Strong, Caoimhe McKenna, Karen Stals, Antonio Vitobello, Mathilde Renaud, Claudine Rieubland, Michel Guipponi, Christophe Philippe, Paul Vrana, Alisa Gaskell, A. Micheil Innes, Alyssa L. Rippert, Rebecca Ahrens‐Nicklas, Elizabeth Bhoj, Kiersten Keller, Bimal P. Chaudhari, Brandon S. Stone   +16 more
wiley   +1 more source