Results 81 to 90 of about 295,712 (230)

Congenital hypothyroidism: insights into pathogenesis and treatment

, 2017
Congenital hypothyroidism occurs in approximately 1 in 2000 newborns and can have devastating neurodevelopmental consequences if not detected and treated promptly.
Christine E. Cherella, Wassner, Ari J., Cherella, Christine, Ari J. Wassner   +3 more
core   +1 more source

Developmental Skills of Children with and Without Congenital Hypothyroidism

Iranian South Medical Journal, 2020
Background: Congenital hypothyroidism is one of the most common endocrinology diseases in children. Given the importance of evaluating the normal growth and development and identifying growth and development abnormalities, this study aimed to evaluate ...
Belghes Rovshan, Afagh Hassanzadeh Rad, Satila Dalili, Ali Reza Gholi Famian   +3 more
doaj  

Infantile Epileptic Spasms Syndrome Complicating Mosaic Down‐Turner Syndrome: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Severe baseline developmental delays in complex genetic syndromes like Down‐Turner mosaicism can completely mask the psychomotor regression of Infantile Epileptic Spasms Syndrome (IESS). Clinicians must maintain a high index of suspicion and prioritize early video‐EEG screening for any abnormal paroxysmal movements.
Mohammad Shahrori, Khadeeja Nofal, Hasan H. Alkhawaja, Waed Mohsen, Ainaa A. Alzamari   +4 more
wiley   +1 more source

Congenital hypothyroidism in neonates

Indian Journal of Endocrinology and Metabolism, 2014
Congenital hypothyroidism (CH) is one of the most common preventable causes of mental retardation in children and it occurs in approximately 1:2,000-1:4,000 newborns.The aim of this study is to determine the frequency of CH in neonates.This cross-sectional study was conducted in neonatal units of the Department of Pediatrics Unit-I, King Edward Medical
Aneela Anjum, Muhammad Faheem Afzal, Syed Muhammad Javed Iqbal, Muhammad Ashraf Sultan, Asif Hanif   +4 more
openaire   +3 more sources

P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
P7C3 activates NAMPT, the rate‐limiting enzyme in the NAD+ salvage pathway, elevating NAD+ levels in neurons. This engages SIRT1‐dependent nuclear signaling and SIRT3‐dependent mitochondrial regulation, enhancing mitochondrial quality control, reducing oxidative stress, and promoting neuronal survival.
Yajing Chen, Xiaohuan Du, Fang Li, Shuwei Yuan, Wenjing Wang, Zengyan Zhu, Mei Wang, Chao Gu   +7 more
wiley   +1 more source

Serum Neudesin Levels in Patients with Congenital Hypothyroidism [PDF]

Objective: Neudesin is a newly discovered protein mainly secreted from adipose tissue and the brain. It plays a role as a neurotrophic factor in the brain and a negative regulator of energy expenditure.
Caner Yıldız, Semra Bahar, İlker Tolga Özgen, Zümrüt Kocabey Sütçü, Emel Hatun Aytaç Kaplan, Yaşar Cesur, Ömer Faruk Özer   +6 more
core   +1 more source

An evaluation of congenital hypothyroidism in Texas, 1992-1995 [PDF]

, 1999
Congenital hypothyroidism is a biochemical defect that can have devastating effects on a child if undetected or untreated. The rate of congenital hypothyroidism in Texas has been on the increase since 1991. Rates in Texas far exceed observed rates nation
Elerian, Nagla F.
core   +2 more sources

Neonatal screening: 9% of children with filter paper thyroid‐stimulating hormone levels between 5 and 10 μIU/mL have congenital hypothyroidism

Jornal de Pediatria (Versão em Português), 2017
Objectives: To determine the prevalence of congenital hypothyroidism in children with filter paper TSH levels (f‐TSH) between 5 and 10 μUI/mL in the neonatal screening. Methods: This was a retrospective study including children screened from 2003 to 2010,
Flávia C. Christensen‐Adad, Carolina T. Mendes‐dos‐Santos, Maura M.F. Goto, Letícia E. Sewaybricker, Lília F.R. D'Souza‐Li, Gil Guerra‐Junior, André M. Morcillo, Sofia Helena V. Lemos‐Marini   +7 more
doaj   +1 more source

Reducing Exposure Before Birth: An Interrupted Time Series Study of Prenatal Exposure to Fetotoxic Medications Under Risk Management Plans in Canada

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 721-730, September 2026.
Canada's 2009 risk management plan (RMP) framework has not been evaluated for prenatal exposure impact. Conversely, widely used drugs such as nonsteroidal anti‐inflammatory drugs (NSAIDs) lack RMPs. We assessed first‐trimester exposure to RMP‐regulated medications following regulatory interventions and to NSAIDs following safety publications.
Nahiyan Saiyara Khan, Odile Sheehy, Lisiane Freitas Leal, Vanina Tchuente, Anick Bérard   +4 more
wiley   +1 more source

Neonatal screening for congenital hypothyroidism in Pakistan [PDF]

, 1989
Congenital hypothyroidism is a preventable cause of mental retardation. Since clinical signs of congenital hypothyroidism do not generally become obvious before three months of age, screening programmes have been introduced in North America and Europe ...
Lakhani, Murntaz, Khurshid, Mohammad, Akber, Mohammad, Naqvi, Shehla H.   +3 more
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