Results 91 to 100 of about 2,057,508 (290)

Cytomegalovirus-Specific T Cell Epitope Recognition in Congenital Cytomegalovirus Mother-Infant Pairs

Frontiers in Immunology, 2020
Background: Congenital cytomegalovirus (cCMV) infection is the most common infection acquired before birth and from which about 20% of infants develop permanent neurodevelopmental effects regardless of presence or absence of symptoms at birth.
Emma C. Materne, Daniele Lilleri, Francesca Garofoli, Giuseppina Lombardi, Milena Furione, Maurizio Zavattoni, Laura Gibson, Laura Gibson, Laura Gibson   +8 more
doaj   +1 more source

Long-term impairment attributable to congenital cytomegalovirus infection: a retrospective cohort study. [PDF]

, 2017
This study aimed to estimate long-term impairment attributable to congenital cytomegalovirus infection (cCMV)
Vossen, Ann C T M, Oudesluys-Murphy, A.M., Melker, H.E. de, Anne Marie Oudesluys-Murphy, Kroes, Aloys C M, Korndewal, Marjolein J, Kroes, A.C.M., de Melker, Hester E., Vossen, A.C.T.M., Hester E de Melker, Ann C T M Vossen, Oudesluys-Murphy, H M Anne Marie, Korndewal, M.J., de Melker, Hester E, Marjolein J Korndewal, van der Sande, Marianne A B, Sande, M.A.B. van der, Aloys C M Kroes, Marianne A B van der Sande, Oudesluys-Murphy, Anne Marie   +19 more
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Development of novel vaccines against human cytomegalovirus

Human Vaccines & Immunotherapeutics, 2019
Congenital human cytomegalovirus (HCMV) infection and HCMV infection of the immunosuppressed patients cause significant morbidity and mortality, and vaccine development against HCMV is a major public health priority. Efforts to develop HCMV vaccines have
Xinle Cui, Clifford M. Snapper
doaj   +1 more source

Ecological comparison of the risks of mother-to-child transmission and clinical manifestations of congenital toxoplasmosis according to prenatal treatment protocol [PDF]

, 2001
We compared the relative risks of mother-to-child transmission of Toxoplasma gondii and clinical manifestations due to congenital toxoplasmosis associated with intensive prenatal treatment in Lyon and Austria, short term treatment in 51% of Dutch women ...
Dunn, D, Prusa, A, Petersen, E, Hayde, M, Kortbeek, T, Peyron, F, Gilbert, R, Pollok, A, Wallon, M, Lebech, M   +9 more
core  

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

In vivo application of recombinant interleukin 2 in the immunotherapy of established cytomegalovirus infection [PDF]

, 1987
We have shown in a murine model system for cytomegalovirus (CMV) disease in the immunocompromised host that in vivo application of recombinant human IL-2 (rhIL-2) can enhance the antiviral effect of a limited number of CD8+T lymphocytes, not only in ...
Reddehase, Matthias J., Koszinowski, Ulrich H., Mutter, Wolfgang   +2 more
core   +2 more sources

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

An immunocompetent mouse model revealed that congenital Zika virus infection disrupted hippocampal function by activating autophagy

Emerging Microbes and Infections
Congenital Zika virus (ZIKV) infection significantly affects neurological development in infants and subsequently induces neurodevelopmental abnormality symptoms; however, the potential mechanism is still unknown.
Wei Yang, Zhan-Zhan Bian, Zhe Li, Yi-Teng Zhang, Li-Bo Liu, Jia-Tong Chang, Dan Li, Pei-Gang Wang, Jing An, Wei Wang   +9 more
doaj   +1 more source