Results 131 to 140 of about 244,983 (239)

Development of Artificial Intelligence for Quantitative Assessment of Nasal Inflammatory Cytology in Chronic Rhinitis by Whole‐Slide Images

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinitis (CR) is currently recognized as a syndrome that manifests in different phenotypes. We aimed to establish an artificial intelligence system (quantitative assessment of nasal inflammatory cytology, QANIC) on the basis of whole‐slide images (WSIs) to enable quantitative assessment of nasal inflammatory cells.
Xu Zhang, Xu Xu, Weiwei Liu, Long Qin, Yu Song, Jingyun Li, Lin Xi, Chengshuo Wang, Luo Zhang, Yuan Zhang   +9 more
wiley   +1 more source

A Noncovalent Click‐to‐Release Strategy to Control Bond Cleavage and Prodrug Activation

Angewandte Chemie, EarlyView.
Extending the click‐to‐release concept beyond covalent ligation, we introduce a noncovalent click‐to‐release strategy based on cucurbituril‐adamantane (CB‐Ad) association. A supramolecular preassembly encapsulating a self‐immolative guest (SIG) is rationally designed to prevent premature release, while adding a high‐affinity Ad guest initiates the CB ...
Xuancheng Fu, Bowen Xu, Suman Maity, Michelle Wu, Luke G. Westbrook, James H. Henderson, Yaoying Wu, Katie A. Edwards, Atanu Acharya, Xiaoran Hu   +9 more
wiley   +2 more sources

¿Estado irresponsable o responsable? La responsabilidad patrimonial del Estado colombiano, luego de la Guerra Civil de 1876-1877 [PDF]

, 2015
Este libro recupera los desarrollos en materia de responsabilidad del Estado realizados por la Corte Suprema Federal colombiana en los años posteriores a la Guerra Civil de 1876 1877, el gobierno intentó suavizar los efectos de los daños patrimoniales ...
Arenas-Mendoza, Hugo Andres
core  

Early and Sustained Improvements in Sense of Smell With Tezepelumab Treatment in Patients With Chronic Rhinosinusitis With Nasal Polyps (WAYPOINT)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Loss of smell is a principal symptom of chronic rhinosinusitis with nasal polyps (CRSwNP), affecting health‐related quality of life and posing a safety hazard. Methods WAYPOINT (NCT04851964), a phase 3, multicenter trial in adults with uncontrolled CRSwNP, randomized patients 1:1 to receive tezepelumab 210 mg or placebo ...
Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrew Foster, Andrew W. Lindsley, Christopher S. Ambrose   +14 more
wiley   +1 more source

Stabilization of the Benzene Radical Trianion in an Inverse‐Sandwich Yttrium Complex

Angewandte Chemie, EarlyView.
A new type of benzene anion state is born: The unprecedented benzene radical trianion embedded in an inverse‐sandwich yttrium complex was synthesized by a one‐electron chemical reduction of its benzene dianion precursor using potassium graphite in the presence of [2.2.2]‐cryptand.
Weiqing Mao, Saroshan Deshapriya, Shenglai Yao, Christian Lorent, Matthias Driess, Selvan Demir   +5 more
wiley   +2 more sources

Local Specific IgE Levels Can Predict and Monitor the Therapeutic Response to Subcutaneous Immunotherapy With House Dust Mite

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Identifying predictive and monitoring biomarkers for allergen immunotherapy response is crucial for enhancing clinical efficacy. This study aims to investigate the systemic and local levels of immunoglobulins and identify potential biomarkers in house dust mite (HDM) allergic rhinitis (AR) patients who are undergoing subcutaneous ...
Xu Xu, Jingyun Li, Xu Zhang, Yu Song, Lin Xi, Luo Zhang, Yuan Zhang   +6 more
wiley   +1 more source

Impedance‐Controlled Multipoint Radiofrequency Ablation for Chronic Rhinitis: A Randomized Controlled Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background The purpose of this randomized controlled trial (RCT) was to demonstrate that posterior nasal nerve ablation treatment with the NEUROMARK System is superior to a sham control procedure in patients with chronic rhinitis. Methods In this prospective, multicenter, single‐blinded, superiority RCT, 132 participants were randomized 2:1 to
Masayoshi Takashima, Randall A. Ow, Richard D. Thrasher, Ellen M. O'Malley, William R. Blythe, Omar G. Ahmed   +5 more
wiley   +1 more source

Dual Circularly Polarized Luminescence from Chiral Boron‐Embedded Polycyclic Aromatic Hydrocarbons

Angewandte Chemie, EarlyView.
Boron‐embedded polycyclic aromatic hydrocarbons featuring an asymmetric boron center coordinated by a proximal P═O group were synthesized. Anthracene‐fused boracyclic derivatives show dual circularly polarized luminescence (CPL) arising from excited‐state P═O⋯B dissociation, which converts point chirality into C−B axial chirality.
Tatsuya Mori, Yoshiharu Sano, Tomoyuki Ikai, Yuuya Kawasaki, Katsuhiko Tomooka, Takahiro Sasamori, Shigehiro Yamaguchi   +6 more
wiley   +2 more sources

Reflexiones sobre la congestión judicial en la jurisdicción contencioso administrativo colombiana

Díkaion, 2002
Este ensayo cuestiona el grave problema que la justicia colombiana afronta en cuanto a la prolongada congestión de los despachos judiciales, particularmente en el ámbito de la Jurisdicción de lo Contencioso Administrativo.
Leonardo Augusto Torres Calderón
doaj  

Optimizing the dengue virus infection mouse model: Comparing different backgrounds and infection route for enhanced stability

Animal Models and Experimental Medicine, EarlyView.
Optimized dengue fever animal model: IFNAR−/− BALB/c mice with intraperitoneal injection. Background screening: Between IFNAR−/− (BALB/c, C57BL/6) and AG129 mice, IFNAR−/−BALB/c exhibited the most severe symptoms: (1) highest weight loss and clinical scores; (2) peak viremia (5.44 log10 RNA copies/mL, day 4); (3) significant organ damage (liver/brain ...
Dan Liao, Ming Zhong, Wenjiang Zheng, Zhendong Guo, Ye Zhou, Qiuhong Li, Lijuan Qiu, Liangwen Yu, Haishan Long, Geng Li   +9 more
wiley   +1 more source