Results 51 to 60 of about 412,338 (234)

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Backbone‐Length‐Optimized Inhibitors Deliver Long‐Retention Selectivity in Area‐Selective ALD of VO2

Advanced Science, EarlyView.
Area‐selective VO2 ALD is found to depend critically on inhibitor backbone length, which governs physisorption, chemisorption stability, and packing efficiency in a coupled manner. An intermediate backbone‐length achieves the best long‐retention selectivity, establishing a chemically and geometrically grounded design principle for small‐molecule ...
Hae Lin Yang, Eun Chong Cho, Minchan Kim, Hye In Park, Ga‐young Lee, Seunghwan Lee, Beomseok Kim, Changhwa Jung, Youngkwon Kim, Jin‐Seong Park   +9 more
wiley   +1 more source

Principales causas de la morosidad en la jurisdicción laboral

Prolegómenos, 2006
El proyecto desarrollado es de gran magnitud e importancia, toda vez que surgen “cascadas de leyes” que al poco tiempo de su vigencia, están siendo modificadas, adicionadas o derogadas, por quienes solucionan todos los problemas de Estado con sus ...
Rafael Ospina Morales
doaj  

Valoración ultrasonográfica de la congestión venosa - VExUS

REV SEN
Doppler de la vena hepática con patrón monofásico pulsátil con inversión sistólica, compatible con elevación de la presión auricular derecha y con congestión venosa sistémica significativa. - inversión o marcada disminución de la onda sistólica -
Washington Xavier Osorio Chuquitarco
doaj   +1 more source

Distribution Locational Marginal Pricing (DLMP) for Congestion Management and Voltage Support

IEEE Transactions on Power Systems, 2018
In this paper, a day-ahead market-clearing model for smart distribution systems is proposed. Various types of distributed energy resources (DERs), such as distributed energy storage, distributed generators, microgrids, and load aggregators, can bid into ...
Linquan Bai, Jianhui Wang, Chengshan Wang, Chen Chen, F. Li   +4 more
semanticscholar   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

La experiencia internacional en peajes urbanos

Cuadernos de Investigación Urbanística, 2008
En los últimos años, sobre todo desde la puesta en marcha del “Congestion Charging” de Londres, en 2003, los peajes urbanos han adquirido una gran relevancia política y adquiriendo un cierto protagonismo en los debates sobre la movilidad urbana y ...
Julio Pozueta Echavarri
doaj  

A Strong Lewis Acidic Diethylsilylium Catalyst for Direct Sulfonamidation of Challenging Ketones

Advanced Science, EarlyView.
Low‐substitution‐order silylium ions (R2HSi+) exhibit exceptional Lewis acidic activity. We report diethylsilylium‐catalyzed reductive sulfonamidation of functionalized ketones to access β‐amino esters. The in situ generated ion pair shows enhanced reactivity, with diethylsilane serving as both reductant and precatalyst. The developed protocol proceeds
Woo Hee Kim, Muhammad Israr, You Kyoung Chung, Shinwon Ham, Joonsuk Huh, Han Yong Bae   +5 more
wiley   +1 more source

Modelado de Tráfico: Una estrategia inteligente contra la congestión de una red

Prisma Tecnológico, 2016
Al momento de implementar una red de telecomunicaciones, no sólo se necesita elegir el protocolo adecuado según el tipo de daos y la velocidad de transmisión que ha de manejar, sino que también se debe tomar en cuenta qué mecanismos de control de tráfico
Daphne Bouche
doaj  

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source