Results 151 to 160 of about 105,103 (246)

Efficacy and Safety of Nanoencapsulated Sirolimus Plus Pegadricase: Results From the Randomized, Placebo‐Controlled Phase 3 Trials

open access: yesArthritis &Rheumatology, EarlyView.
Objective DISSOLVE I and II examined the efficacy and safety of nanoencapsulated sirolimus (NAS) plus pegadricase (NASP) in patients with uncontrolled gout (UG). Methods In these double‐blind, placebo‐controlled Phase 3 trials of NASP, patients were randomized 1:1:1 to infusions of high‐dose (HD) or low‐dose (LD) NAS plus pegadricase (HD NASP, LD NASP,
Herbert S. B. Baraf   +15 more
wiley   +1 more source

Pharmacokinetics, effectiveness and safety of certolizumab pegol in children and adolescents with active juvenile idiopathic arthritis: 9+‐year results from a multicenter, open‐label study

open access: yesArthritis &Rheumatology, Accepted Article.
Objective To assess the pharmacokinetics, effectiveness, safety, and immunogenicity of certolizumab pegol (CZP) in polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods Pediatric Arthritis Study of Certolizumab Pegol (NCT01550003), a multicenter, open‐label study, enrolled patients 2–17 years with active pcJIA and inadequate response ...
Hermine I Brunner   +28 more
wiley   +1 more source

Congestion control for a fair packet delivery in WSN: from a complex system perspective. [PDF]

open access: yesScientificWorldJournal, 2014
Aguirre-Guerrero D   +3 more
europepmc   +1 more source

Single‐Staged Combined Retrograde Subchondral Drilling and In Situ Autologous or Micronized Cartilage Repair With Bone Marrow Aspirate Concentrate for Focal Patellofemoral Chondral Lesions

open access: yesArthroscopy Techniques, EarlyView.
Abstract Patellofemoral cartilage lesions are uniquely challenging to treat due to high joint contact pressures, complex tracking mechanics, and limited intrinsic healing potential. Conventional methods such as debridement, microfracture, or staged autologous chondrocyte implantation may disrupt the calcified cartilage layer, violate the subchondral ...
S. Ali Ghasemi   +5 more
wiley   +1 more source

Synergetic Combination of Carbon Xerogels, Graphene Oxide and nano‐ZnO for Aqueous and Organic Supercapacitors

open access: yesBatteries &Supercaps, Volume 8, Issue 3, March 2025.
This work proposes the synthesis of carbon‐based nanostructured materials obtained using ZnO as both nanos‐ template and catalysts simultaneously. During the synthesis, GO was used as a stabiliser, preventing the collapse of the 3D structure and improving its properties in terms of capacitance and surface area.
Rusbel Coneo‐Rodríguez   +5 more
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić   +7 more
wiley   +1 more source

Mobile health interventions to improve adherence to oral anticoagulant treatment: A systematic review and critical analysis

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Non‐adherence to oral anticoagulants (OACs) is associated with significant morbidity and mortality. Mobile health (mHealth) interventions have been used to improve medication adherence across the three phases of initiation, implementation and persistence.
Non Davies   +2 more
wiley   +1 more source

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