Results 251 to 260 of about 59,062 (321)

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

An appropriate DNA input for bisulfite conversion reveals LINE-1 and Alu hypermethylation in tissues and circulating cell-free DNA from cancers. [PDF]

PLoS One
Tran TTQ, Pham TT, Nguyen TT, Hien Do T, Luu PTT, Nguyen UQ, Vuong LD, Nguyen QN, Ho SV, Dao HV, Hoang TV, Vo LTT.   +11 more
europepmc   +1 more source

Highlighting Recent Progress in Fiber Energy Harvesters: From Working Principles to Future Perspectives

Advanced Science, EarlyView.
Fiber energy harvesters offer unprecedented flexibility and a unique capacity for integration into commercial textiles, overcoming the limitations of bulky and rigid conventional devices. This review summarizes recent advances in fiber‐based energy harvesting and provides strategic outlooks to accelerate technological progress in the field. ABSTRACT As
Hanhwi Jang, Junseong Ahn, Yongrok Jeong, Sohee Jeon, Soon Hyoung Hwang, Min‐Wook Oh, Jun‐Ho Jeong, Inkyu Park, Yeon Sik Jung   +8 more
wiley   +1 more source

Stability of Inverse Problems for Steady Supersonic Flows Past Lipschitz Perturbed Cones. [PDF]

Arch Ration Mech Anal
Chen GG, Pu Y, Zhang Y.
europepmc   +1 more source

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Double stochastic resonance in stink bug sexual communication. [PDF]

Sci Rep
Curcio L, Spezia S, Valenti D, Mosunov S, Denaro G, Peri E, Colazza S, Marsella G, Spagnolo B.   +8 more
europepmc   +1 more source

Early Radiation Therapy Response Assessment Using Multi‐Scale Photoacoustic Imaging

Advanced Science, EarlyView.
Tomographic and mesoscopic photoacoustics capture intratumoural features of radioresistance and response. ABSTRACT There is a critical unmet clinical need to identify biomarkers that predict and detect radiation therapy (RT) response in cancer. Using the unique capabilities of multi‐scale photoacoustic imaging (PAI) to depict tumor oxygenation and ...
Thierry L. Lefebvre, Mariam‐Eleni Oraiopoulou, Ellie V. Bunce, Thomas R. Else, Lorna C. Wright, Monika A. Golinska, Lina Hacker, Cara Brodie, Steven Kupczak, Yi Cheng, Lisa Young, Paul W. Sweeney, Sarah E. Bohndiek   +12 more
wiley   +1 more source

Data-driven nucleus subclassification on colon hematoxylin and eosin using style-transferred digital pathology. [PDF]

J Med Imaging (Bellingham)
Remedios LW, Bao S, Remedios SW, Lee HH, Cai LY, Li T, Deng R, Newlin NR, Saunders AM, Cui C, Li J, Liu Q, Lau KS, Roland JT, Washington MK, Coburn LA, Wilson KT, Huo Y, Landman BA.   +18 more
europepmc   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

A case study of the three-dimensional co-seismic ionospheric disturbance evolution. [PDF]

Sci Rep
Song R, Hattori K, Zhang X, Liu JY, Yoshino C.   +4 more
europepmc   +1 more source