Results 151 to 160 of about 45,405 (265)

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

X-ray contrast-adjustable 3D printing for multimodal fusion of microCT and histology. [PDF]

Front Med Technol
Nolte P, Ackurat CJ, Brettmacher M, Reichardt M, Stammes M, Rußmann C, Dullin C.   +6 more
europepmc   +1 more source

Clock genes regulate Ca2+ signaling and mitochondrial bioenergetics to inhibit Sjogren's disease

Arthritis &Rheumatology, Accepted Article.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjogren's disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA seq, and mitochondrial activity were used to investigate the effects of ...
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento Da Conceicao, Neelanjan Vishnu, Shankara N Varadarajan, Venugopal R. Bovilla, Rajender K Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Protocol for multi-organ isolation of murine leukocytes for flow cytometry. [PDF]

STAR Protoc
Layug PJ, Marcinow A, Sontag D, Mendelson AA, Arsenio J.   +4 more
europepmc   +1 more source

Impact of Process Interruptions in the Production of Lysates for Cell‐Free Expression Systems

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cell‐free gene expression systems offer cell‐like functionalities outside the confines of the cell, garnering increasing interest for applications from biomanufacturing to sensing. As applications expand, the need to implement economically scaled processes to produce cellular lysates grows.
Katherine A. Rhea, Ethan N. Walters, Julie L. Zacharko, Mia J. Seergae, Thomas R. Laws, Thomas C. Maishman, Yun‐Nam Choi, John T. Lazar, Ashty Karim, Weston Kightlinger, Michael C. Jewett, Matthew W. Lux   +11 more
wiley   +1 more source

Experimental Evaluation of a Concealed Anchoring System for Large-Format Thin Ceramic Panels Under Wind Loading in Ventilated Façades. [PDF]

Materials (Basel)
Roviras Miñana J, Sarrablo Moreno V, Casariego Vales P.   +2 more
europepmc   +1 more source

Design Principles for Next Generation of Small Organic Molecules for Photodynamics Therapy Revealed by Nonadiabatic Molecular Dynamics

Chemistry – A European Journal, EarlyView.
Molecular design reshapes the landscape of excited‐state relaxation. Nonadiabatic dynamics reveal how electronic structure guides population flow between competing pathways beyond static energetic arguments. ABSTRACT Nitrobenzochalcogenadiazole derivatives are emerging candidates for photodynamic therapy (PDT), yet the precise mechanisms governing ...
Vinícius N. da Rocha, Davide Avagliano, Paulo C. Piquini   +2 more
wiley   +1 more source

The post-translational adaptor protein SadB modulates the pathogenicity of <i>Pseudomonas aeruginosa</i>. [PDF]

J Bacteriol
Papangeli M, Luckett J, Heeb S, Alexander MR, Williams P, Dubern J-F.   +5 more
europepmc   +1 more source

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly. [PDF]

Proc Natl Acad Sci U S A
Gupta M, Waltmann C, Renner N, Wang Y, James LC, Jacques DA, Böcking T, Voth GA.   +7 more
europepmc   +1 more source