Results 121 to 130 of about 871,047 (310)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
JACOBIAN CONJECTURE, TWO-DIMENSIONAL CASE
Проблемы анализа, 2016 The Jacobian Conjecture was first formulated by O. Keller in 1939. In the modern form it supposes injectivity of the polynomial mapping f: R^n → R^n (C^n → C^n) provided that jacobian J_f ≡ const ≠ 0.
V. V. Starkov
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Homological conjectures and stable equivalences of Morita type
AIMS MathematicsLet $ A $ and $ B $ be two finite-dimensional algebras over an algebraically closed field. Suppose that $ A $ and $ B $ are stably equivalent of Morita type; we prove that $ A $ satisfies the Auslander–Reiten conjecture (resp.
Juxiang Sun, Guoqiang Zhao
doaj +1 more source
The long-COVID-19 in older adults: facts and conjectures
, 2022 Tino Emanuele Poloni +3 more
openalex +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
On Traces, Clues, and Fiction: Carlo Ginzburg and the Practice of Archaeology
Open ArchaeologyIn recent years, archaeological research has relied on large datasets, both temporally and geographically, with some archaeologists discussing that there should be a shift towards a more scientific form of conducting archaeological research called ...
Ribeiro Artur
doaj +1 more source
Minimum output entropy of bosonic channels: A conjecture [PDF]
, 2004 Vittorio Giovannetti +4 more
openalex +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source