Results 171 to 180 of about 865,901 (361)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Advancements in Research Mathematics through AI: A Framework for Conjecturing [PDF]
, 2023 Randy Davila
openalex +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
The normalizer splitting conjecture for p-compact groups [PDF]
, 1999 Kasper K. S. Andersen
openalex +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
A finite-dimensional approach to the strong Novikov conjecture [PDF]
, 2013 Daniel A. Ramras +2 more
openalex +1 more source
The rank 8 case of a conjecture on square-zero upper triangular matrices [PDF]
, 2020 Berrin Şentürk
openalex +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Manin's conjecture on a nonsingular quartic del Pezzo surface [PDF]
, 2009 Fok-Shuen Leung
openalex +1 more source
Greenberg's conjecture and Leopoldt's conjecture
Proceedings of the Japan Academy, Series A, Mathematical Sciences, 2000 Let \(p\) be an odd prime number and \(G\) the non-abelian group of order \(p^3\) and exponent \(p\). The author shows there exists Galois extensions \(L\) of \({\mathbb Q}\) with group \(G\) and vanishing Iwasawa invariants \(\lambda,\mu\) and \(\nu\) for the cyclotomic \({\mathbb Z}_p\)-extension of \(L\).
openaire +3 more sources