Results 91 to 100 of about 230,316 (281)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Enhancing Conjugate Gradient Method Through a Novel Investigation Parameter For Unconstrained Minimization [PDF]

open access: yesمجلة التربية والعلم
Conjugate gradient algorithms come in a wide range of flavors. The conjugate gradient technique primarily concentrates on the spectral parameter. It follows the standard method proposed by Hastens and Stiefel, In this study, we have devised an innovative
Abd Hassan, Hamsa Saeed
doaj   +1 more source

Preconditioned conjugate-gradient methods for low-speed flow calculations [PDF]

open access: yes
An investigation is conducted into the viability of using a generalized Conjugate Gradient-like method as an iterative solver to obtain steady-state solutions of very low-speed fluid flow problems.
Ajmani, Kumud   +2 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

An Accelerated Riemannian Conjugate Gradient Method Based on the Barzilai–Borwein Technique

open access: yesMathematics
This paper proposes an accelerated Riemannian conjugate gradient method based on the Barzilai-Borwein (BB) technique, termed ABBSRCG, for unconstrained optimization on Riemannian manifolds. Building upon classical Riemannian conjugate gradient frameworks,
Ziyin Ma, Tao Yan, Shimin Zhao
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

A scaled three-term conjugate gradient method for unconstrained optimization

open access: yesJournal of Inequalities and Applications, 2016
Conjugate gradient methods play an important role in many fields of application due to their simplicity, low memory requirements, and global convergence properties.
Ibrahim Arzuka   +2 more
doaj   +1 more source

Stochastic optimization methods for the simultaneous control of parameter-dependent systems

open access: yes, 2020
We address the application of stochastic optimization methods for the simultaneous control of parameter-dependent systems. In particular, we focus on the classical Stochastic Gradient Descent (SGD) approach of Robbins and Monro, and on the recently ...
Biccari, Umberto   +2 more
core  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Some descent Dai-Liao-type conjugate gradient methods for vector optimization

open access: yesFranklin Open
Conjugate gradient methods play a crucial role in solving unconstrained optimization problems and have recently been extended to vector optimization problems (VOPs).
Jamilu Yahaya   +2 more
doaj   +1 more source

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