Results 111 to 120 of about 77,026 (328)

Rational Development of a Novel Emulgel Adjuvant for Single‐Shot Effective Vaccination: A Multivariate Analysis Approach

Advanced Materials, EarlyView.
Using multivariate analysis, a novel emulgel adjuvant is developed by combining key nanoemulsion formulation variables–hydrogel trapping, small globule size, and mannide monooleate surfactant–achieving 10× greater immunogenicity than MF59 in mice after a single shot.
Ahmed O. Shalash, Waleed M. Hussein, Ummey J. Nahar, Jingwen Wang, Lantian Lu, Armira Azuar, Jolynn J. E. Kiong, Prashamsa Koirala, Zeinab G. Khalil, Istvan Toth   +9 more
wiley   +1 more source

AUGMENTED ANTIBODY (Ab) RESPONSES IN INFANTS ADMINISTERED A NEW HAEMOPHILUS INFLUENZAE TYPE B CAPSULAR POLYSACCHARIDE (PRP) DIPHTHERIA TOXOID CONJUGATE VACCINE (PRP-D) [PDF]

, 1984
John M. Zahradnik, Lance Gordon
openalex   +1 more source

Zinc‐Coordinated Trienzyme Nanogel Cascade Therapy for Accelerated Post‐Pancreatectomy Cutaneous Wound Healing

Advanced Materials, EarlyView.
A zinc‐coordinated nanogel assembly is reported that co‐delivers three enzymes to regulate glucose, oxidative stress, and oxygen levels. This system mimics natural enzyme cascades to reprogram the wound environment after pancreatectomy. In a post‐pancreatectomy mouse model, it accelerates healing by reducing infection, promoting blood vessel growth ...
Yedong Ma, Chengke Xie, Chengyu Liao, Binting Huang, Siqi Liu, Junhua Kong, Xiaotong Fan, Zibiao Li, Shi Chen, Chaobin He   +9 more
wiley   +1 more source

17. HAEMOPHILUS INFLUENZAE TYPE B CONJUGATE VACCINE (PRP-D) PROTECTS FROM BACTEREMIC DISEASES IN INFANCY [PDF]

, 1988
Juhani Eskola, Aino K. Takala, Hejkki Peltola, Helena Käyhty, Helena Mäkelä   +4 more
openalex   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Immunogenicity and Efficacy of Different Haemophilus influenzae type b Vaccines

Archives of Razi Institute, 2014
Haemophilus influenzae, a major cause of meningitis in young children leading to death and other neurological sequelae. The disease leaves 15 to 35% of the survivors with permanent disabilities, such as, mental retardation or deafness.
Mojgani, N.
doaj  

Progress towards the development of Klebsiella vaccines

Expert Review of Vaccines, 2019
Introduction: Klebsiella pneumoniae (KP) are a leading cause of healthcare-associated infections. The dramatic increase in microbial resistance to third-generation cephalosporin and carbapenem ‘front line’ antimicrobial agents and the paucity of new ...
Myeongjin Choi, Sharon M Tennant, Raphael Simon, Alan S Cross   +3 more
doaj   +1 more source

A Three Component Synthetic Vaccine Containing a β-Mannan T-Cell Peptide Epitope and a β-Glucan Dendritic Cell Ligand

Molecules, 2018
Glycoconjugates prepared from the capsular polysaccharide of several pathogenic bacteria and carrier proteins, such as CRM 197 or tetanus toxoid, have been one of the most successful public health measures to be implemented in the last quarter century. A
David R. Bundle, Eugenia Paszkiewicz, Hassan R. H. Elsaidi, Satadru Sekhar Mandal, Susmita Sarkar   +4 more
doaj   +1 more source

ADULT-LIKE ANTIBODY (Ab) RESPONSES TO HAEMOPHILUS INFLUENZAE b (HIB) CAPSULAR POLYSACCHARIDE (PRP) VACCINE IN HUMAN INFANTS PRIMED WITH PROTEIN-OLIGOSACCHARIDE CONJUGATE VACCINES [PDF]

, 1987
Michael E. Pichichero, Richard A. Insel, Porter Anderson   +2 more
openalex   +1 more source

Artificial Intelligence‐Driven Nanoarchitectonics for Smart Targeted Drug Delivery

Advanced Materials, EarlyView.
This perspective introduces an artificial intelligence (AI)‐driven nanoarchitectonics framework for targeted drug delivery, combining database‐guided nanocarrier design, machine learning (ML)‐assisted surface engineering with a designed targeting system, and in silico modeling for dynamic optimization.
Hayeon Bae, Hyunsub Ji, Konstantin Konstantinov, Ronald Sluyter, Katsuhiko Ariga, Yong Ho Kim, Jung Ho Kim   +6 more
wiley   +1 more source