Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. [PDF]
, 2012 Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes.
Adegbola, Richard A +18 more
core +2 more sources
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source
AUGMENTED ANTIBODY (Ab) RESPONSES IN INFANTS ADMINISTERED A NEW HAEMOPHILUS INFLUENZAE TYPE B CAPSULAR POLYSACCHARIDE (PRP) DIPHTHERIA TOXOID CONJUGATE VACCINE (PRP-D) [PDF]
, 1984 John M. Zahradnik, Lance Gordon
openalex +1 more source
Nanoscale Biodegradable Printing for Designed Tuneability of Vaccine Delivery Kinetics
Advanced Materials, Volume 37, Issue 15, April 16, 2025.Spatiotemporal Controlled Release Inks of Biocompatible polyEsters (SCRIBE) is a novel 2PP resin family with sub‐micron resolution and tuneable hydrolysis. SCRIBE enables direct printing of hollow microparticles with complex chemistries and geometries inaccessible to molding techniques, which are used to modulate antibody titers and class switching as ...
David J. Peeler +16 more
wiley +1 more source
Oligosaccharide-protein conjugate vaccines induce and prime for oligoclonal IgG antibody responses to the Haemophilus influenzae b capsular polysaccharide in human infants. [PDF]
, 1986 Richard A. Insel, P. W. Anderson
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Impact of conjugation chemistry on the immunogenicity of S. Typhimurium conjugate vaccines
Vaccine, 2014 Salmonella Typhimurium is major cause of invasive nontyphoidal Salmonella disease in Africa. Conjugation of S. Typhimurium O-antigen to an appropriate carrier protein constitutes a possible strategy for the development of a vaccine against this disease, for which no vaccines are currently available.
Stefanetti, G +5 more
openaire +4 more sources
Off‐The‐Shelf Multivalent Nanoconjugate Cancer Vaccine Rescues Host Immune Response against Melanoma
Advanced Materials, Volume 37, Issue 16, April 23, 2025.A star‐shaped cross‐linked polyglutamate (StCl) nanocarrier delivers melanoma‐associated peptide antigens via redox‐responsive linkers, inducing lymph node‐targeted antigen presentation. The nanoconjugate activates dendritic cells, promotes effector T‐cell responses, and enables tumor regression even in humanized patient‐derived preclinical models ...
Liane IF Moura +19 more
wiley +1 more source
Progress towards the development of Klebsiella vaccines
Expert Review of Vaccines, 2019 Introduction: Klebsiella pneumoniae (KP) are a leading cause of healthcare-associated infections. The dramatic increase in microbial resistance to third-generation cephalosporin and carbapenem ‘front line’ antimicrobial agents and the paucity of new ...
Myeongjin Choi +3 more
doaj +1 more source
Preparation and immunochemical characterization of meningococcal group C polysaccharide-tetanus toxoid conjugates as a new generation of vaccines [PDF]
, 1983 E. C. Beuvery +3 more
openalex +1 more source
Micro‐ and Nano‐Bots for Infection Control
Advanced Materials, EarlyView.This review presents a strategic vision for integrating micro‐ and nanobots in the pipeline for infection diagnosis, prevention, and treatment. To develop these robots as a practical solution for infection management, their design principles are clarified based on their propulsion mechanisms and then categorized infection management domains based on ...
Azin Rashidy Ahmady +5 more
wiley +1 more source