Results 161 to 170 of about 46,055 (312)

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Effectiveness and impact of 7 and 13-valent pneumococcal conjugate vaccines in Chinese children: A systematic review and meta-analysis. [PDF]

Hum Vaccin Immunother
Peng R, Zhang T, Dunne EM, Xu Z, Sun A, Cheng J, Yang J, Zhao G.   +7 more
europepmc   +1 more source

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

The Complex Landscape of Updated Pneumococcal Conjugate Vaccines. [PDF]

Open Forum Infect Dis
Thindwa D, Shapiro ED, Weinberger DM.
europepmc   +1 more source

AIEgen‐Based Proactive Early Warning System and Precise Treatment Strategy for Monkeypox Prevention and Control

Advanced Science, EarlyView.
An intelligent early warning and treatment system for monkeypox, utilizing a sprayable AIEgen‐ liquid dressing (AIE@LD) that responds to lesion pH. Integrated with a smartphone app and cloud platform, it enables real‐time infection detection via fluorescence imaging and triggers on‐demand photodynamic therapy under white light, effectively eradicating ...
Wei Wang, Zining Liu, Mengjun Li, Judun Zheng, Ruilin Zhang, Ke Liu, Xiaoxue Li, Shaoying Wen, Jingze Yu, Meijia Pan, Fengbo Ma, Kun Zhou, Zheng Zhao, Chenguang Shen, Yuhui Liao   +14 more
wiley   +1 more source

Bacterial Acute Otitis Media Complicated with Otorrhea in a Children's Hospital in the Era of Pneumococcal Conjugate Vaccines. [PDF]

Pathogens
Tzovara I, Doudoulakakis A, Kalogeras G, Koutouzis E, Dellis C, Pasparakis S, Charakida M, Lebessi E, Bozavoutoglou E, Tsakanikos M, Syriopoulou V, Tsolia M.   +11 more
europepmc   +1 more source

Salivary antibodies following parenteral immunization of infants with a meningococcal serogroup A and C conjugated vaccine [PDF]

, 1999
Ray Borrow, Andrew J. Fox, K Cartwright, Norman Begg, D. M. Jones   +4 more
openalex   +1 more source

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Vaccines as antimicrobial resistance control tools: evidence from pneumococcal conjugate vaccines in South Africa. [PDF]

Pan Afr Med J
Iwu-Jaja C, Mazingisa AV, Jaca A, Iwu CD, Wiysonge CS.   +4 more
europepmc   +1 more source

Evaluation of a diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b vaccine given concurrently with meningococcal group C conjugate vaccine at 2, 3 and 4 months of age [PDF]

, 2006
Nicholas Kitchin, Jo Southern, Rob Morris, Fabienne Hemme, Spencer A. Thomas, Michael Watson, Keith Cartwright, Emma R. Miller   +7 more
openalex   +1 more source